CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021599
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Retinoid-inducible serine carboxypeptidase 
Protein Synonyms/Alias
 Serine carboxypeptidase 1 
Gene Name
 SCPEP1 
Gene Synonyms/Alias
 RISC; SCP1; MSTP034; UNQ265/PRO302 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
243QVLNAVNKGLYREATubiquitination[1, 2, 3, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May be involved in vascular wall and kidney homeostasis (By similarity). 
Sequence Annotation
 ACT_SITE 167 167 By similarity.
 ACT_SITE 371 371 By similarity.
 ACT_SITE 431 431 By similarity.
 CARBOHYD 64 64 N-linked (GlcNAc...) (Potential).
 CARBOHYD 126 126 N-linked (GlcNAc...).
 CARBOHYD 362 362 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Carboxypeptidase; Complete proteome; Direct protein sequencing; Glycoprotein; Hydrolase; Polymorphism; Protease; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 452 AA 
Protein Sequence
MELALRRSPV PRWLLLLPLL LGLNAGAVID WPTEEGKEVW DYVTVRKDAY MFWWLYYATN 60
SCKNFSELPL VMWLQGGPGG SSTGFGNFEE IGPLDSDLKP RKTTWLQAAS LLFVDNPVGT 120
GFSYVNGSGA YAKDLAMVAS DMMVLLKTFF SCHKEFQTVP FYIFSESYGG KMAAGIGLEL 180
YKAIQRGTIK CNFAGVALGD SWISPVDSVL SWGPYLYSMS LLEDKGLAEV SKVAEQVLNA 240
VNKGLYREAT ELWGKAEMII EQNTDGVNFY NILTKSTPTS TMESSLEFTQ SHLVCLCQRH 300
VRHLQRDALS QLMNGPIRKK LKIIPEDQSW GGQATNVFVN MEEDFMKPVI SIVDELLEAG 360
INVTVYNGQL DLIVDTMGQE AWVRKLKWPE LPKFSQLKWK ALYSDPKSLE TSAFVKSYKN 420
LAFYWILKAG HMVPSDQGDM ALKMMRLVTQ QE 452 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0004185; F:serine-type carboxypeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0042573; P:retinoic acid metabolic process; IEA:Compara. 
Interpro
 IPR001563; Peptidase_S10.
 IPR018202; Peptidase_S10_AS. 
Pfam
 PF00450; Peptidase_S10 
SMART
  
PROSITE
 PS00560; CARBOXYPEPT_SER_HIS
 PS00131; CARBOXYPEPT_SER_SER 
PRINTS
 PR00724; CRBOXYPTASEC.