| Tag | Content |
|---|
| CPLM ID | CPLM-021707 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Multifunctional protein ADE2 |
Protein Synonyms/Alias | Protein adenosine-5; Phosphoribosylaminoimidazole-succinocarboxamide synthase; SAICAR synthetase; Phosphoribosylaminoimidazole carboxylase; AIR carboxylase; AIRC |
Gene Name | ade5 |
Gene Synonyms/Alias | CG3989 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 58 | KAHDLAGKAEISNTT | acetylation | [1] | | 84 | GIRTAYVKQCGAKAF | acetylation | [1] | | 115 | LATGSFLKRNVGVPE | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | |
Sequence Annotation | REGION 7 264 SAICAR synthetase.
REGION 265 429 AIR carboxylase. |
Keyword | ATP-binding; Complete proteome; Decarboxylase; Ligase; Lyase; Multifunctional enzyme; Nucleotide-binding; Purine biosynthesis; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 429 AA |
Protein Sequence | MSTTTTASIE GYKLGKVIIE GKTKQVYDLP EQPGLCLLLS KDRITAGDGV KAHDLAGKAE 60
ISNTTNGQVF RLLNEAGIRT AYVKQCGAKA FIARKCQMIP IEWVTRRLAT GSFLKRNVGV 120
PEGYRFSPPK QETFFKDDAN HDPQWSEEQI VSAKFELNGL VIGQDEVDIM RRTTLLVFEI 180
LERAWQTKNC ALIDMKVEFG ICDDGNIVLA DIIDSDSWRL WPAGDKRLMV DKQVYRNLAS 240
VTASDLDTVK RNFIWVAEQL ADIVPKKDHL VVILMGSASD ISHSEKIATS CRSLGLNVEL 300
RVSSAHKGPE ETLRIVREYE SVMSNLIFVA VAGRSNGLGP VVSGSTNYPV INCPPVKSDN 360
MQVDVWSSLN LPSGLGCATV LYPEAAALHA ATILGLGNFM VWSKLRVKAL NNFITLKKAD 420
KELRGVRNA 429 |
Gene Ontology | GO:0034023; F:5-(carboxyamino)imidazole ribonucleotide mutase activity; IEA:InterPro. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004638; F:phosphoribosylaminoimidazole carboxylase activity; TAS:UniProtKB. GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; TAS:UniProtKB. GO:0006189; P:'de novo' IMP biosynthetic process; IMP:FlyBase. GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase. GO:0002121; P:inter-male aggressive behavior; IMP:FlyBase. GO:0009113; P:purine nucleobase biosynthetic process; IGI:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |