CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024824
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphatase and tensin homolog, isoform CRA_a 
Protein Synonyms/Alias
 Protein Pten; Protein tyrosine phosphatase and tensin homolog/mutated in multiple advanced cancers protein; Protein tyrosine phosphatase and tensin-like protein 
Gene Name
 Pten 
Gene Synonyms/Alias
 PTEN/MMAC1; rCG_47874 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
266HKQNKMLKKDKMFHFacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 3D-structure; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 403 AA 
Protein Sequence
MTAIIKEIVS RNKRRYQEDG FDLDLTYIYP NIIAMGFPAE RLEGVYRNNI DDVVRFLDSK 60
HKNHYKIYNL CAERHYDTAK FNCRVAQYPF EDHNPPQLEL IKPFCEDLDQ WLSEDDNHVA 120
AIHCKAGKGR TGVMICAYLL HRGKFLKAQE ALDFYGEVRT RDKKGVTIPS QRRYVYYYSY 180
LLKNHLDYRP VALLFHKMMF ETIPMFSGGT CNPQFVVCQL KVKIYSSNSG PTRREDKLMY 240
FEFPQPLPVC GDIKVEFFHK QNKMLKKDKM FHFWVNTFFI PGPEETSEKV ENGSLCDQEI 300
DSICSIERAD NDKEYLVLTL TKNDLDKANK DKANRYFSPN FKVKLYFTKT VEEPSNPEAS 360
SSTSVTPDVS DNEPDHYRYS DTTDSDPENE PFDEDQHSQI TKV 403 
Gene Ontology
 GO:0043197; C:dendritic spine; IDA:RGD.
 GO:0009898; C:internal side of plasma membrane; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0035749; C:myelin sheath adaxonal region; IEA:Compara.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0045211; C:postsynaptic membrane; IDA:RGD.
 GO:0043220; C:Schmidt-Lanterman incisure; IEA:Compara.
 GO:0051717; F:inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; IEA:Compara.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0016314; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; IDA:RGD.
 GO:0051800; F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; IEA:Compara.
 GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IEA:Compara.
 GO:0005161; F:platelet-derived growth factor receptor binding; IDA:RGD.
 GO:0004722; F:protein serine/threonine phosphatase activity; IEA:Compara.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:Compara.
 GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; TAS:RGD.
 GO:0007092; P:activation of mitotic anaphase-promoting complex activity; IEA:Compara.
 GO:0007568; P:aging; IEP:RGD.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0048738; P:cardiac muscle tissue development; IEA:Compara.
 GO:0032286; P:central nervous system myelin maintenance; IEA:Compara.
 GO:0021955; P:central nervous system neuron axonogenesis; IEA:Compara.
 GO:0060997; P:dendritic spine morphogenesis; IEA:Compara.
 GO:0021542; P:dentate gyrus development; IEA:Compara.
 GO:0043542; P:endothelial cell migration; IEA:Compara.
 GO:0048853; P:forebrain morphogenesis; IEA:Compara.
 GO:0006917; P:induction of apoptosis; TAS:RGD.
 GO:0046855; P:inositol phosphate dephosphorylation; IEA:Compara.
 GO:0045475; P:locomotor rhythm; IEA:Compara.
 GO:0060292; P:long term synaptic depression; IMP:RGD.
 GO:0060291; P:long-term synaptic potentiation; IEA:Compara.
 GO:0060179; P:male mating behavior; IEA:Compara.
 GO:0042711; P:maternal behavior; IEA:Compara.
 GO:0007613; P:memory; IMP:RGD.
 GO:0033555; P:multicellular organismal response to stress; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0050771; P:negative regulation of axonogenesis; IEA:Compara.
 GO:0090344; P:negative regulation of cell aging; IEA:Compara.
 GO:0030336; P:negative regulation of cell migration; TAS:RGD.
 GO:0008285; P:negative regulation of cell proliferation; IDA:RGD.
 GO:0045792; P:negative regulation of cell size; IEA:Compara.
 GO:0031658; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; IEA:Compara.
 GO:0061002; P:negative regulation of dendritic spine morphogenesis; IEA:Compara.
 GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Compara.
 GO:0090394; P:negative regulation of excitatory postsynaptic membrane potential; IEA:Compara.
 GO:0051895; P:negative regulation of focal adhesion assembly; IEA:Compara.
 GO:0031642; P:negative regulation of myelination; IEA:Compara.
 GO:0046621; P:negative regulation of organ growth; IEA:Compara.
 GO:0050765; P:negative regulation of phagocytosis; IMP:RGD.
 GO:0051898; P:negative regulation of protein kinase B signaling cascade; IEA:Compara.
 GO:0090071; P:negative regulation of ribosome biogenesis; IEA:Compara.
 GO:2000808; P:negative regulation of synaptic vesicle clustering; IEA:Compara.
 GO:0031175; P:neuron projection development; IDA:RGD.
 GO:0007270; P:neuron-neuron synaptic transmission; IEA:Compara.
 GO:0046856; P:phosphatidylinositol dephosphorylation; IMP:RGD.
 GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IDA:RGD.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential; IEA:Compara.
 GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Compara.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0097107; P:postsynaptic density assembly; IEA:Compara.
 GO:0060134; P:prepulse inhibition; IEA:Compara.
 GO:0097105; P:presynaptic membrane assembly; IEA:Compara.
 GO:0060736; P:prostate gland growth; IEA:Compara.
 GO:0043491; P:protein kinase B signaling cascade; IEA:Compara.
 GO:0050821; P:protein stabilization; IEA:Compara.
 GO:0002902; P:regulation of B cell apoptotic process; IEA:Compara.
 GO:0033032; P:regulation of myeloid cell apoptotic process; IEA:Compara.
 GO:0046685; P:response to arsenic-containing substance; IEP:RGD.
 GO:0033198; P:response to ATP; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0032355; P:response to estradiol stimulus; IEP:RGD.
 GO:0045471; P:response to ethanol; IEP:RGD.
 GO:0009749; P:response to glucose stimulus; IEP:RGD.
 GO:0007584; P:response to nutrient; IEP:RGD.
 GO:0010043; P:response to zinc ion; IEP:RGD.
 GO:0060024; P:rhythmic synaptic transmission; IEA:Compara.
 GO:0035176; P:social behavior; IEA:Compara.
 GO:0060074; P:synapse maturation; IEA:Compara. 
Interpro
 IPR017361; Bifunc_PIno_P3_Pase/Pase_PTEN.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR000340; Dual-sp_phosphatase_cat-dom.
 IPR014019; Phosphatase_tensin-typ.
 IPR014020; Tensin_phosphatase_C2-dom.
 IPR016130; Tyr_Pase_AS. 
Pfam
 PF00782; DSPc
 PF10409; PTEN_C2 
SMART
  
PROSITE
 PS51182; C2_TENSIN
 PS51181; PPASE_TENSIN
 PS00383; TYR_PHOSPHATASE_1 
PRINTS