UniProt Accession

 BHMT1_HUMAN; Q93088; Q9UNI9 

Genbank Protein ID

 U50929; AF118378; AF118371; AF118372; AF118373; AF118374; AF118375; AF118376; AF118377; BC012616 

Genbank Nucleotide ID

 AAC50668.1; AAD22043.1; AAD22043.1; AAD22043.1; AAD22043.1; AAD22043.1; AAD22043.1; AAD22043.1; AAD22043.1; AAH12616.1 

Protein Name

 Betaine--homocysteine S-methyltransferase 1 

Protein Synonyms/Alias

  

Gene Name

 BHMT 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
369	PYNPSMSKPDGWGVT	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. 

Sequence Annotation

 DOMAIN 11 314 Hcy-binding.
 METAL 217 217 Zinc.
 METAL 299 299 Zinc.
 METAL 300 300 Zinc.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Metal-binding; Methyltransferase; Polymorphism; Reference proteome; Transferase; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 406 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0047150; F:betaine-homocysteine S-methyltransferase activity; NAS:UniProtKB.
 GO:0008898; F:homocysteine S-methyltransferase activity; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006579; P:amino-acid betaine catabolic process; IEA:UniProtKB-UniPathway.
 GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.
 GO:0009086; P:methionine biosynthetic process; IEA:Compara.
 GO:0006479; P:protein methylation; NAS:UniProtKB.
 GO:0050666; P:regulation of homocysteine metabolic process; NAS:UniProtKB.
 GO:0000096; P:sulfur amino acid metabolic process; TAS:Reactome. 

Interpro

 IPR017226; Betaine-hCys_S-MeTrfase_BHMT.
 IPR003726; S_MeTrfase. 

Pfam

 PF02574; S-methyl_trans 

SMART

  

PROSITE

 PS50970; HCY 

PRINTS