UniProt Accession

 CALCA_HUMAN; P06881; Q93048; Q9UCP0 

Genbank Protein ID

 M12667; M12664; M12665; X15943; AC090835; K03512; X02330; M28637; M26094 

Genbank Nucleotide ID

 AAA51914.1; AAA51914.1; AAA51914.1; CAA34070.1; AAA52011.1; CAA26190.1; AAA52012.1; AAA51912.1 

Protein Name

 Calcitonin gene-related peptide 1 

Protein Synonyms/Alias

 Alpha-type CGRP; Calcitonin gene-related peptide I; CGRP-I 

Gene Name

 CALCA 

Gene Synonyms/Alias

 CALC1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
106	SRSGGVVKNNFVPTN	acetylation	[1]
117	VPTNVGSKAFGRRRR	acetylation	[1]

Reference

 [1] Investigation of the structure/activity relationship of human calcitonin gene-related peptide (CGRP).
 Tippins JR, Di Marzo V, Panico M, Morris HR, MacIntyre I.
 Biochem Biophys Res Commun. 1986 Feb 13;134(3):1306-11. [PMID: 3484952] 

Functional Description

 CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. 

Sequence Annotation

 MOD_RES 119 119 Phenylalanine amide.
 DISULFID 84 89  

Keyword

 3D-structure; Alternative splicing; Amidation; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disulfide bond; Hormone; Polymorphism; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 128 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005615; C:extracellular space; IDA:UniProtKB.
 GO:0032403; F:protein complex binding; IDA:UniProtKB.
 GO:0005102; F:receptor binding; IDA:UniProtKB.
 GO:0007190; P:activation of adenylate cyclase activity; IDA:UniProtKB.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0051482; P:elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; IDA:UniProtKB.
 GO:0043542; P:endothelial cell migration; IDA:UniProtKB.
 GO:0001935; P:endothelial cell proliferation; IDA:UniProtKB.
 GO:0002031; P:G-protein coupled receptor internalization; IDA:UniProtKB.
 GO:0007159; P:leukocyte cell-cell adhesion; IDA:UniProtKB.
 GO:0045776; P:negative regulation of blood pressure; IDA:MGI.
 GO:0045779; P:negative regulation of bone resorption; IDA:UniProtKB.
 GO:0010523; P:negative regulation of calcium ion transport into cytosol; IDA:UniProtKB.
 GO:0045671; P:negative regulation of osteoclast differentiation; IDA:UniProtKB.
 GO:0001976; P:neurological system process involved in regulation of systemic arterial blood pressure; IDA:MGI.
 GO:0032730; P:positive regulation of interleukin-1 alpha production; IDA:UniProtKB.
 GO:0032757; P:positive regulation of interleukin-8 production; IDA:UniProtKB.
 GO:0045651; P:positive regulation of macrophage differentiation; IDA:UniProtKB.
 GO:0045909; P:positive regulation of vasodilation; IDA:UniProtKB.
 GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
 GO:0008217; P:regulation of blood pressure; NAS:UniProtKB.
 GO:0001944; P:vasculature development; IDA:UniProtKB.
 GO:0042311; P:vasodilation; IEA:InterPro. 

Interpro

 IPR018360; Calcitonin_CS.
 IPR001693; Calcitonin_peptide-like.
 IPR021117; Procalcitonin-like.
 IPR021116; Procalcitonin/adrenomedullin.
 IPR015476; Procalcitonin_gene-rel_peptide. 

Pfam

 PF00214; Calc_CGRP_IAPP 

SMART

 SM00113; CALCITONIN 

PROSITE

 PS00258; CALCITONIN 

PRINTS

 PR00817; CALCITONINB.