CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007185
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Polyhomeotic-proximal chromatin protein 
Protein Synonyms/Alias
  
Gene Name
 ph-p 
Gene Synonyms/Alias
 CG18412 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
1223TPNSVSGKEEPKLATacetylation[1]
1570PALKIVAKVESIKEVacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Plays a role in regulating the expression of other pair-rule genes such as eve, ftz, and H. 
Sequence Annotation
 DOMAIN 1513 1577 SAM.
 ZN_FING 1356 1389 FCS-type.
 MOD_RES 1145 1145 Phosphoserine.
 MOD_RES 1148 1148 Phosphothreonine.  
Keyword
 3D-structure; Complete proteome; Developmental protein; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1589 AA 
Protein Sequence
MDRRALKFMQ KRADTESDTT TPVSTTASQG ISASAILAGG TLPLKDNSNI REKPLHHNYN 60
HNNNNSSQHS HSHQQQQQQQ VGGKQLERPL KCLETLAQKA GITFDEKYDV ASPPHPGIAQ 120
QQATSGTGPA TGSGSVTPTS HRHGTPPTGR RQTHTPSTPN RPSAPSTPNT NCNSIARHTS 180
LTLEKAQNPG QQVAATTTVP LQISPEQLQQ FYASNPYAIQ VKQEFPTHTT SGSGTELKHA 240
TNIMEVQQQL QLQQQLSEAN GGGAASAGAG GAASPANSQQ SQQQQHSTAI STMSPMQLAA 300
ATGGVGGDWT QGRTVQLMQP STSFLYPQMI VSGNLLHPGG LGQQPIQVIT AGKPFQGNGP 360
QMLTTTTQNA KQMIGGQAGF AGGNYATCIP TNHNQSPQTV LFSPMNVISP QQQQNLLQSM 420
AAAAQQQQLT QQQQQFNQQQ QQQLTQQQQQ LTAALAKVGV DAQGKLAQKV VQKVTTTSSA 480
VQAATGPGST GSTQTQQVQQ VQQQQQQTTQ TTQQCVQVSQ STLPVGVGGQ SVQTAQLLNA 540
GQAQQMQIPW FLQNAAGLQP FGPNQIILRN QPDGTQGMFI QQQPATQTLQ TQQNQIIQCN 600
VTQTPTKART QLDALAPKQQ QQQQQVGTTN QTQQQQLAVA TAQLQQQQQQ LTAAALQRPG 660
APVMPHNGTQ VRPASSVSTQ TAQNQSLLKA KMRNKQQPVR PALATLKTEI GQVAGQNKVV 720
GHLTTVQQQQ QATNLQQVVN AAGNKMVVMS TTGTPITLQN GQTLHAATAA GVDKQQQQLQ 780
LFQKQQILQQ QQMLQQQIAA IQMQQQQAAV QAQQQQQQQV SQQQQVNAQQ QQAVAQQQQA 840
VAQAQQQQRE QQQQVAQAQA QHQQALANAT QQILQVAPNQ FITSHQQQQQ QQLHNQLIQQ 900
QLQQQAQAQV QAQVQAQAQQ QQQQREQQQN IIQQIVVQQS GATSQQTSQQ QQHHQSGQLQ 960
LSSVPFSVSS STTPAGIATS SALQAALSAS GAIFQTAKPG TCSSSSPTSS VVTITNQSST 1020
PLVTSSTVAS IQQAQTQSAQ VHQHQQLISA TIAGGTQQQP QGPPSLTPTT NPILAMTSMM 1080
NATVGHLSTA PPVTVSVTST AVTSSPGQLV LLSTASSGGG GSIPATPTKE TPSKGPTATL 1140
VPIGSPKTPV SGKDTCTTPK SSTPATVSAS VEASSSTGEA LSNGDASDRS STPSKGATTP 1200
TSKQSNAAVQ PPSSTTPNSV SGKEEPKLAT CGSLTSATST STTTTITNGI GVARTTASTA 1260
VSTASTTTTS SGTFITSCTS TTTTTTSSIS NGSKDLPKAM IKPNVLTHVI DGFIIQEANE 1320
PFPVTRQRYA DKDVSDEPPK KKATMQEDIK LSGIASAPGS DMVACEQCGK MEHKAKLKRK 1380
RYCSPGCSRQ AKNGIGGVGS GETNGLGTGG IVGVDAMALV DRLDEAMAEE KMQTEATPKL 1440
SESFPILGAS TEVPPMSLPV QAAISAPSPL AMPLGSPLSV ALPTLAPLSV VTSGAAPKSS 1500
EVNGTDRPPI SSWSVDDVSN FIRELPGCQD YVDDFIQQEI DGQALLLLKE KHLVNAMGMK 1560
LGPALKIVAK VESIKEVPPP GEAKDPGAQ 1589 
Gene Ontology
 GO:0005730; C:nucleolus; IDA:FlyBase.
 GO:0035102; C:PRC1 complex; IDA:FlyBase.
 GO:0051087; F:chaperone binding; IDA:FlyBase.
 GO:0003682; F:chromatin binding; IDA:FlyBase.
 GO:0001047; F:core promoter binding; IDA:FlyBase.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0021954; P:central nervous system neuron development; IMP:FlyBase.
 GO:0016458; P:gene silencing; IGI:FlyBase.
 GO:0030708; P:germarium-derived female germ-line cyst encapsulation; IMP:FlyBase.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:FlyBase.
 GO:0030713; P:ovarian follicle cell stalk formation; IMP:FlyBase.
 GO:0035075; P:response to ecdysone; IMP:FlyBase.
 GO:0035186; P:syncytial blastoderm mitotic cell cycle; IMP:FlyBase. 
Interpro
 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR011510; SAM_2.
 IPR012313; Znf_FCS. 
Pfam
 PF07647; SAM_2 
SMART
 SM00454; SAM 
PROSITE
 PS50105; SAM_DOMAIN
 PS51024; ZF_FCS 
PRINTS