UniProt Accession

 YEFM_ECOLI; P69346; P46147; P76371 

Genbank Protein ID

 U00096; AP009048; V00284 

Genbank Nucleotide ID

 AAC75078.2; BAA15849.2 

Protein Name

 Antitoxin YefM 

Protein Synonyms/Alias

  

Gene Name

 yefM 

Gene Synonyms/Alias

 b2017; JW5835 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
19	NLSATMMKAVEDHAP	acetylation	[1]
72	MDSIDSLKSGKGTEK	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Antitoxin component of a toxin-antitoxin (TA) module. Antitoxin that counteracts the effect of the YoeB toxin. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; DNA-binding; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 83 AA 

Protein Sequence

Gene Ontology

 GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
 GO:0015643; F:toxic substance binding; IDA:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR006442; Antitoxin_Phd/YefM. 

Pfam

 PF02604; PhdYeFM_antitox 

SMART

  

PROSITE

  

PRINTS