UniProt Accession

 STRAA_HUMAN; Q7RTN6; B4DDE3; B4DW17; J3KTC9; Q5JPI2; Q7Z4K9; Q8NC31; Q8NCF1; Q9H272 

Genbank Protein ID

 AF308302; AY290821; AK074771; AK075005; AK293160; AK301331; AL832407; AC015651; AC046185; CH471109; BK001542 

Genbank Nucleotide ID

 AAG48269.1; AAP42280.1; BAC11197.1; BAC11349.1; BAG56704.1; BAG62879.1; CAI46194.1; EAW94283.1; DAA01797.1 

Protein Name

 STE20-related kinase adapter protein alpha 

Protein Synonyms/Alias

 STRAD alpha; STE20-related adapter protein; Serologically defined breast cancer antigen NY-BR-96 

Gene Name

 STRADA 

Gene Synonyms/Alias

 LYK5; STRAD 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
91	TVNLARYKPTGEYVT	ubiquitination	[1]
239	DFPKYSVKVLPWLSP	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. 

Sequence Annotation

 DOMAIN 69 379 Protein kinase.
 MOD_RES 329 329 Phosphothreonine; by LKB1.
 MOD_RES 419 419 Phosphothreonine; by LKB1.  

Keyword

 3D-structure; Alternative splicing; ATP-binding; Cell cycle; Chromosomal rearrangement; Complete proteome; Cytoplasm; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 431 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0030295; F:protein kinase activator activity; IDA:UniProtKB.
 GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
 GO:0032147; P:activation of protein kinase activity; IDA:UniProtKB.
 GO:0007050; P:cell cycle arrest; TAS:Reactome.
 GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.
 GO:0006611; P:protein export from nucleus; IDA:UniProtKB. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom. 

Pfam

 PF00069; Pkinase 

SMART

  

PROSITE

 PS50011; PROTEIN_KINASE_DOM 

PRINTS