UniProt Accession

 GPX4_HUMAN; P36969; O43381; Q6PJ59; Q9UPK2 

Genbank Protein ID

 X71973; AF060972; AY324108; AC004151; AC005390; BC011836; BC021567; BC022071; BC032695; BC039849 

Genbank Nucleotide ID

 CAA50793.1; AAC32261.1; AAP72965.1; AAC03239.1; AAC28920.1; AAH11836.1; AAH21567.1; AAH22071.1; AAH32695.3; AAH39849.1 

Protein Name

 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial 

Protein Synonyms/Alias

 PHGPx; Glutathione peroxidase 4; GPx-4; GSHPx-4 

Gene Name

 GPX4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
47	SMHEFSAKDIDGHMV	acetylation	[1]
162	GILGNAIKWNFTKFL	ubiquitination	[2]
167	AIKWNFTKFLIDKNG	ubiquitination	[2]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity). 

Sequence Annotation

 ACT_SITE 73 73  

Keyword

 3D-structure; Alternative initiation; Complete proteome; Cytoplasm; Developmental protein; Mitochondrion; Oxidoreductase; Peroxidase; Polymorphism; Reference proteome; Selenocysteine; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 197 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005739; C:mitochondrion; TAS:UniProtKB.
 GO:0004602; F:glutathione peroxidase activity; TAS:UniProtKB.
 GO:0047066; F:phospholipid-hydroperoxide glutathione peroxidase activity; IEA:EC.
 GO:0019369; P:arachidonic acid metabolic process; TAS:Reactome.
 GO:0019372; P:lipoxygenase pathway; TAS:Reactome.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0006644; P:phospholipid metabolic process; TAS:UniProtKB.
 GO:0006979; P:response to oxidative stress; IEA:InterPro. 

Interpro

 IPR000889; Glutathione_peroxidase.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00255; GSHPx 

SMART

  

PROSITE

 PS00460; GLUTATHIONE_PEROXID_1
 PS00763; GLUTATHIONE_PEROXID_2
 PS51355; GLUTATHIONE_PEROXID_3 

PRINTS