CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038198
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 7 
Protein Synonyms/Alias
  
Gene Name
 Usp7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
295TEGDDSSKSVPLALQubiquitination[1]
363CVEGTIPKLFRGKMVubiquitination[1]
396YDIQLSIKGKKNIFEubiquitination[1]
480PLDEFLQKTDPKDPAubiquitination[1]
865MNYFQVAKTVAQRLNacetylation[2]
865MNYFQVAKTVAQRLNubiquitination[1]
910RDLLQFFKPRQPKKLacetylation[2]
910RDLLQFFKPRQPKKLubiquitination[1]
923KLYYQQLKMKITDFEubiquitination[1]
1125LGLDHFNKAPKRSRYacetylation[2, 3]
1137SRYTYLEKAIKIHN*ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1143 AA 
Protein Sequence
MASSTSPPRS PSGRILTQDT IYFPQSNIIS ELLPWYLRYT PPEVPSTSVI TKFILVNCPW 60
NEGIEYQAGD TDDPPRITQN PVINGNVTLS DGHSNAEEDM EDDTSWRSEA TFQFTVERFS 120
RLSESVLSPP CFVRNLPWKI MVMPRFYPDR PHQKSVGFFL QCNAESDSTS WSCHAQAVLK 180
IINYRDDDKS FSRRISHLFF HKENDWGFSN FMAWSEVTDP EKGFIDDDKV TFEVFVQADA 240
PHGVAWDSKK HTGYVGLKNQ GATCYMNSLL QTLFFTNQLR KAVYMMPTEG DDSSKSVPLA 300
LQRVFYELQH SDKPVGTKKL TKSFGWETLD SFMQHDVQEL CRVLLDNVEN KMKGTCVEGT 360
IPKLFRGKMV SYIQCKDVDY RSDRREDYYD IQLSIKGKKN IFESFVDYVA VEQLDGDNKY 420
DAGEHGLQEA EKGVKFLTLP PVLHLQLMRF MYDPQTDQNI KINDRFEFPE QLPLDEFLQK 480
TDPKDPANYI LHAVLVHSGD NHGGHYVVYL NPKGDGKWCK FDDDVVSRCT KEEAIEHNYG 540
GHDDDLSVRH CTNAYMLVYI RESKLSEVLQ AVTDHDIPQQ LVERLQEEKR IEAQKRKERQ 600
EAHLYMQVQI VAEDQFCGHQ GNDMYDEEKV RYTVFKVLKN SSLAEFVQSL SQTMGFPQDQ 660
IRLWPMQARS NGTKRPAMLD NEADGNKTMI ELSDNENPWT IFLETVDPEL AASGATLPKF 720
DKDHDVMLFL KMYDPKTRSL NYCGHIYTPI SCKIRDLLPV MCDRAGFIQD TSLILYEEVK 780
PNLTERIQDY DVSLDKALDE LMDGDIIVFQ KDDPENDNSE LPTAKEYFRD LYHRVDVIFC 840
DKTIPNDPGF VVTLSNRMNY FQVAKTVAQR LNTDPMLLQF FKSQGYRDGP GNPLRHNYEG 900
TLRDLLQFFK PRQPKKLYYQ QLKMKITDFE NRRSFKCIWL NSQFREEEIT LYPDKHGCVR 960
DLLEECKKAV ELGDKASGRL RLLEIVSYKI IGVHQEDELL ECLSPATSRT FRIEEIPLDQ 1020
VDIDKENEML ITVAHFHKEV FGTFGIPFLL RIHQGEHFRE VMKRIQSLLD IQEKEFEKFK 1080
FAIVMMGRHQ YINEDEYEVN LKDFEPQPGN MSHPRPWLGL DHFNKAPKRS RYTYLEKAIK 1140
IHN 1143 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR002083; MATH.
 IPR024729; Pept_C19_dom.
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19.
 IPR008974; TRAF-like. 
Pfam
 PF00917; MATH
 PF00443; UCH
 PF12436; USP7 
SMART
 SM00061; MATH 
PROSITE
 PS50144; MATH
 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3 
PRINTS