CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004803
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Retinoic acid receptor RXR-alpha 
Protein Synonyms/Alias
 Nuclear receptor subfamily 2 group B member 1; Retinoid X receptor alpha 
Gene Name
 RXRA 
Gene Synonyms/Alias
 NR2B1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
108VSSSEDIKPPLGLNGsumoylation[1]
145CGDRSSGKHYGVYSCacetylation[2]
Reference
 [1] Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1.
 Choi SJ, Chung SS, Rho EJ, Lee HW, Lee MH, Choi HS, Seol JH, Baek SH, Bang OS, Chung CH.
 J Biol Chem. 2006 Oct 13;281(41):30669-77. [PMID: 16912044]
 [2] Orphan receptor TR3 attenuates the p300-induced acetylation of retinoid X receptor-alpha.
 Zhao WX, Tian M, Zhao BX, Li GD, Liu B, Zhan YY, Chen HZ, Wu Q.
 Mol Endocrinol. 2007 Dec;21(12):2877-89. [PMID: 17761950] 
Functional Description
 Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes. 
Sequence Annotation
 DNA_BIND 135 200 Nuclear receptor.
 ZN_FING 135 155 NR C4-type.
 ZN_FING 171 195 NR C4-type.
 REGION 1 134 Modulating (By similarity).
 REGION 201 224 Hinge.
 REGION 225 462 Ligand-binding.
 MOD_RES 21 21 Phosphoserine (By similarity).
 MOD_RES 27 27 Phosphoserine.
 MOD_RES 56 56 Phosphoserine; by MAPK8 and MAPK9 (By
 MOD_RES 70 70 Phosphoserine; by MAPK8 and MAPK9 (By
 MOD_RES 82 82 Phosphothreonine; by MAPK8 and MAPK9 (By
 MOD_RES 260 260 Phosphoserine; by MAPK8 and MAPK9 (By
 CROSSLNK 108 108 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 3D-structure; Complete proteome; DNA-binding; Host-virus interaction; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 462 AA 
Protein Sequence
MDTKHFLPLD FSTQVNSSLT SPTGRGSMAA PSLHPSLGPG IGSPGQLHSP ISTLSSPING 60
MGPPFSVISS PMGPHSMSVP TTPTLGFSTG SPQLSSPMNP VSSSEDIKPP LGLNGVLKVP 120
AHPSGNMASF TKHICAICGD RSSGKHYGVY SCEGCKGFFK RTVRKDLTYT CRDNKDCLID 180
KRQRNRCQYC RYQKCLAMGM KREAVQEERQ RGKDRNENEV ESTSSANEDM PVERILEAEL 240
AVEPKTETYV EANMGLNPSS PNDPVTNICQ AADKQLFTLV EWAKRIPHFS ELPLDDQVIL 300
LRAGWNELLI ASFSHRSIAV KDGILLATGL HVHRNSAHSA GVGAIFDRVL TELVSKMRDM 360
QMDKTELGCL RAIVLFNPDS KGLSNPAEVE ALREKVYASL EAYCKHKYPE QPGRFAKLLL 420
RLPALRSIGL KCLEHLFFFK LIGDTPIDTF LMEMLEAPHQ MT 462 
Gene Ontology
 GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0004886; F:9-cis retinoic acid receptor activity; TAS:ProtInc.
 GO:0031490; F:chromatin DNA binding; IEA:Compara.
 GO:0046982; F:protein heterodimerization activity; IDA:UniProtKB.
 GO:0044323; F:retinoic acid-responsive element binding; IDA:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0003713; F:transcription coactivator activity; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0060038; P:cardiac muscle cell proliferation; IEA:Compara.
 GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.
 GO:0008203; P:cholesterol metabolic process; TAS:BHF-UCL.
 GO:0007566; P:embryo implantation; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0001893; P:maternal placenta development; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0035357; P:peroxisome proliferator activated receptor signaling pathway; IDA:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; IEA:Compara.
 GO:0032526; P:response to retinoic acid; IMP:BHF-UCL.
 GO:0060528; P:secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; IEA:Compara.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
 GO:0055012; P:ventricular cardiac muscle cell differentiation; IEA:Compara.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Compara.
 GO:0019048; P:virus-host interaction; IDA:UniProtKB.
 GO:0006766; P:vitamin metabolic process; TAS:ProtInc. 
Interpro
 IPR021780; Nuc_recep-AF1.
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR000003; Retinoid-X_rcpt/HNF4.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00104; Hormone_recep
 PF11825; Nuc_recep-AF1
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR00545; RETINOIDXR.
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.