UniProt Accession

 AL1B1_MOUSE; Q9CZS1; Q3UAH5 

Genbank Protein ID

 AK012213; AK088396; AK150992; AK151349; AK151364; AK153416; BC020001; BC086768 

Genbank Nucleotide ID

 BAB28101.1; BAC40326.1; BAE30016.1; BAE30325.1; BAE30339.1; BAE31976.1; AAH20001.1; AAH86768.1 

Protein Name

 Aldehyde dehydrogenase X, mitochondrial 

Protein Synonyms/Alias

 Aldehyde dehydrogenase family 1 member B1 

Gene Name

 Aldh1b1 

Gene Synonyms/Alias

 Aldhx 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
53	EWHDAVSKKTFPTVN	acetylation	[1]
274	EVGHLIQKAAGESNL	acetylation	[2]
366	QQGPQVDKEQFERIL	acetylation	[1, 2, 3, 4, 5]
366	QQGPQVDKEQFERIL	succinylation	[4]
381	GYIRLGQKEGAKLLC	acetylation	[1]
385	LGQKEGAKLLCGGER	acetylation	[1, 2, 4]
385	LGQKEGAKLLCGGER	succinylation	[4]
401	GERGFFIKPTVFGDV	acetylation	[1, 2, 3, 4, 5]
401	GERGFFIKPTVFGDV	succinylation	[4]
401	GERGFFIKPTVFGDV	ubiquitination	[6]
416	QDGMRIAKEEIFGPV	acetylation	[1, 2, 3, 4, 5]
416	QDGMRIAKEEIFGPV	succinylation	[4]
416	QDGMRIAKEEIFGPV	ubiquitination	[6]
428	GPVQPLFKFKKIEEV	acetylation	[1, 2, 3, 4, 5]
428	GPVQPLFKFKKIEEV	succinylation	[4]
430	VQPLFKFKKIEEVIQ	acetylation	[1]
431	QPLFKFKKIEEVIQR	acetylation	[1, 2, 4]
431	QPLFKFKKIEEVIQR	succinylation	[4]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [6] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (By similarity). 

Sequence Annotation

 NP_BIND 264 269 NAD (By similarity).
 ACT_SITE 287 287 Proton acceptor (By similarity).
 ACT_SITE 321 321 Nucleophile (By similarity).  

Keyword

 Complete proteome; Mitochondrion; NAD; Oxidoreductase; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 519 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IEA:EC.
 GO:0006068; P:ethanol catabolic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom. 

Pfam

 PF00171; Aldedh 

SMART

  

PROSITE

 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 

PRINTS