UniProt Accession

 PIGC_HUMAN; Q92535; O14491 

Genbank Protein ID

 D85418; AB000360; BT006734; CR450292; Z97195; BC006539 

Genbank Nucleotide ID

 BAA12812.1; BAA22866.1; AAP35380.1; CAG29288.1; CAB10071.1; AAH06539.1 

Protein Name

 Phosphatidylinositol N-acetylglucosaminyltransferase subunit C 

Protein Synonyms/Alias

 Phosphatidylinositol-glycan biosynthesis class C protein; PIG-C 

Gene Name

 PIGC 

Gene Synonyms/Alias

 GPI2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
10	AQPVTNTKEVKWQKV	ubiquitination	[1]
16	TKEVKWQKVLYERQP	ubiquitination	[1]
289	PWDEAEIKEDLSRFL	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. 

Sequence Annotation

  

Keyword

 Complete proteome; Endoplasmic reticulum; Glycosyltransferase; GPI-anchor biosynthesis; Membrane; Polymorphism; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 297 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0000506; C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0003824; F:catalytic activity; TAS:ProtInc.
 GO:0017176; F:phosphatidylinositol N-acetylglucosaminyltransferase activity; IEA:EC.
 GO:0006501; P:C-terminal protein lipidation; TAS:Reactome.
 GO:0016254; P:preassembly of GPI anchor in ER membrane; TAS:Reactome. 

Interpro

 IPR009450; Plno_GlcNAc_GPI2. 

Pfam

 PF06432; GPI2 

SMART

  

PROSITE

  

PRINTS