UniProt Accession

 SRFB1_HUMAN; Q8NEF9; Q5QFI2; Q96AH4; Q96DK2 

Genbank Protein ID

 AY611630; AK058015; CH471086; BC017102; BC031222 

Genbank Nucleotide ID

 AAU25829.2; BAB71631.1; EAW48900.1; AAH17102.1; AAH31222.1 

Protein Name

 Serum response factor-binding protein 1 

Protein Synonyms/Alias

 SRF-dependent transcription regulation-associated protein; p49/STRAP 

Gene Name

 SRFBP1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
86	GDDINFEKIFKKPDS	ubiquitination	[1, 2, 3]
423	NIAVFQGKKITFDD*	acetylation	[4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). 

Sequence Annotation

 MOD_RES 203 203 Phosphoserine.
 MOD_RES 205 205 Phosphoserine.
 MOD_RES 264 264 Phosphoserine.
 MOD_RES 279 279 Phosphoserine.
 MOD_RES 281 281 Phosphoserine.  

Keyword

 Coiled coil; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 429 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR015158; Bud-site_select_BUD22. 

Pfam

 PF09073; BUD22 

SMART

  

PROSITE

  

PRINTS