UniProt Accession

 ZRAB2_HUMAN; O95218; D3DQ75; Q53GS3; Q59F92; Q5VV33; Q5VV34; Q8IXN6; Q9UP63 

Genbank Protein ID

 AF065391; AF065392; AL136945; AB209568; AK222858; AL512443; AL512443; CH471059; CH471059; BC039814 

Genbank Nucleotide ID

 AAD09746.1; AAD09747.1; CAB66879.1; BAD92805.1; BAD96578.1; CAH70058.1; CAH70059.1; EAX06433.1; EAX06435.1; AAH39814.1 

Protein Name

 Zinc finger Ran-binding domain-containing protein 2 

Protein Synonyms/Alias

 Zinc finger protein 265; Zinc finger, splicing 

Gene Name

 ZRANB2 

Gene Synonyms/Alias

 ZIS; ZNF265 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
54	AGGTEIGKTLAEKSR	acetylation	[1, 2, 3]
59	IGKTLAEKSRGLFSA	acetylation	[3]
168	DEDLSKYKLDEDEDE	ubiquitination	[4]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'- splice site selection. 

Sequence Annotation

 ZN_FING 9 40 RanBP2-type 1.
 ZN_FING 65 94 RanBP2-type 2.
 REGION 151 324 Required for nuclear targeting.
 MOD_RES 9 9 Phosphoserine.
 MOD_RES 54 54 N6-acetyllysine.
 MOD_RES 114 114 Phosphotyrosine (By similarity).
 MOD_RES 120 120 Phosphoserine.
 MOD_RES 153 153 Phosphoserine.
 MOD_RES 181 181 Phosphoserine.
 MOD_RES 188 188 Phosphoserine.
 MOD_RES 193 193 Phosphoserine.
 MOD_RES 290 290 Phosphoserine (By similarity).
 MOD_RES 294 294 Phosphoserine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Metal-binding; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 330 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0003723; F:RNA binding; TAS:ProtInc.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; TAS:ProtInc. 

Interpro

 IPR017337; UCP037956_Znf_RanB2.
 IPR001876; Znf_RanBP2. 

Pfam

 PF00641; zf-RanBP 

SMART

 SM00547; ZnF_RBZ 

PROSITE

 PS01358; ZF_RANBP2_1
 PS50199; ZF_RANBP2_2 

PRINTS