CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010122
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Ribonucleoside-diphosphate reductase subunit beta 
Protein Synonyms/Alias
 Ribonucleotide reductase small subunit 
Gene Name
 nrdF 
Gene Synonyms/Alias
 MPN_322; MP514 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
20SPLEYAQKKFQGNLRacetylation[1]
153VKTESLQKRAKALIPacetylation[1]
165LIPYYTGKDPLKSKVacetylation[1]
239KEKQAEMKRFVFDLMacetylation[1]
299TEEETRIKPEIFAQLacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). 
Sequence Annotation
 ACT_SITE 125 125 By similarity.
 METAL 87 87 Iron 1 (By similarity).
 METAL 121 121 Iron 1 (By similarity).
 METAL 215 215 Iron 2.  
Keyword
 Complete proteome; DNA replication; Iron; Metal-binding; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 339 AA 
Protein Sequence
MANTKKYFLE SVSPLEYAQK KFQGNLRSVN WNLVDDEKDL EVWNRITQNF WLPEKIPVSN 60
DIPSWKQLSK EWQDLITKTF TGLTLLDTIQ ATIGDIKQID YALTDHEQVI YANFAFMVGV 120
HARSYGTIFS TLCTSEQITE AHEWVVKTES LQKRAKALIP YYTGKDPLKS KVAAALMPGF 180
LLYGGFYLPF YLSSRKQLPN TSDIIRLILR DKVIHNYYSG YKFQRKVEKM SKEKQAEMKR 240
FVFDLMYELI ELEKAYLKEL YEGFGIVEDA IKFSIYNAGK FLQNLGYDSP FTEEETRIKP 300
EIFAQLSARA DENHDFFSGN GSSYVMGISE ETEDKDWDF 339 
Gene Ontology
 GO:0005971; C:ribonucleoside-diphosphate reductase complex; IEA:InterPro.
 GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.
 GO:0046914; F:transition metal ion binding; IEA:InterPro.
 GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.
 GO:0009263; P:deoxyribonucleotide biosynthetic process; IEA:InterPro.
 GO:0006260; P:DNA replication; IEA:UniProtKB-UniPathway. 
Interpro
 IPR009078; Ferritin-like_SF.
 IPR012348; RNR-rel.
 IPR026494; RNR_1b_NrdF.
 IPR000358; RNR_small. 
Pfam
 PF00268; Ribonuc_red_sm 
SMART
  
PROSITE
 PS00368; RIBORED_SMALL 
PRINTS