| Tag | Content |
|---|
| CPLM ID | CPLM-008787 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Adenine deaminase |
Protein Synonyms/Alias | ADE; Adenine aminohydrolase; AAH |
Gene Name | AAH1 |
Gene Synonyms/Alias | YNL141W; N1208; N1825 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 329 | KGSWCDDKRKNGLLS | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. Also exhibits a low activity towards N(6)-substituted adenines that are commonly known as the plant hormones cytokinins. |
Sequence Annotation | ACT_SITE 207 207 Proton donor (By similarity).
METAL 16 16 Zinc; catalytic (By similarity).
METAL 18 18 Zinc; catalytic (By similarity).
METAL 204 204 Zinc; catalytic (By similarity).
METAL 285 285 Zinc; catalytic (By similarity).
BINDING 286 286 Substrate (By similarity). |
Keyword | Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Nucleotide metabolism; Nucleus; Reference proteome; Ubl conjugation; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 347 AA |
Protein Sequence | MVSVEFLQEL PKCEHHLHLE GTLEPDLLFP LAKRNDIILP EGFPKSVEEL NEKYKKFRDL 60
QDFLDYYYIG TNVLISEQDF FDLAWAYFKK VHKQGLVHAE VFYDPQSHTS RGISIETVTK 120
GFQRACDKAF SEFGITSKLI MCLLRHIEPE ECLKTIEEAT PFIKDGTISA LGLDSAEKPF 180
PPHLFVECYG KAASLNKDLK LTAHAGEEGP AQFVSDALDL LQVTRIDHGI NSQYDEELLD 240
RLSRDQTMLT ICPLSNVKLQ VVQSVSELPL QKFLDRDVPF SLNSDDPAYF GGYILDVYTQ 300
VSKDFPHWDH ETWGRIAKNA IKGSWCDDKR KNGLLSRVDE VVTKYSH 347 |
Gene Ontology | GO:0005829; C:cytosol; IBA:RefGenome. GO:0005634; C:nucleus; IDA:SGD. GO:0000034; F:adenine deaminase activity; IGI:UniProtKB. GO:0008270; F:zinc ion binding; IEA:HAMAP. GO:0006146; P:adenine catabolic process; IGI:UniProtKB. GO:0043103; P:hypoxanthine salvage; IDA:SGD. GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW. GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |