UniProt Accession

 2A5G_HUMAN; Q13362; B4DYJ8; B5BUA5; F5GWP3; Q14391; Q15060; Q15174; Q6ZN33 

Genbank Protein ID

 U37352; Z69030; AK131391; AK302470; AB451341; AL118558; AL137779; CH471061; D26445; L42375 

Genbank Nucleotide ID

 AAC50387.1; CAA93154.1; BAD18542.1; BAG63760.1; BAG70155.1; EAW81756.1; BAA05465.1; AAC37603.1 

Protein Name

 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform 

Protein Synonyms/Alias

 PP2A B subunit isoform B'-gamma; PP2A B subunit isoform B56-gamma; PP2A B subunit isoform PR61-gamma; PP2A B subunit isoform R5-gamma; Renal carcinoma antigen NY-REN-29 

Gene Name

 PPP2R5C 

Gene Synonyms/Alias

 KIAA0044 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
291	PVVMALLKYWPKTHS	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. 

Sequence Annotation

 MOTIF 416 422 Nuclear localization signal (Potential).
 MOD_RES 497 497 Phosphoserine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Centromere; Chromosome; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 524 AA 

Protein Sequence

Gene Ontology

 GO:0000775; C:chromosome, centromeric region; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0000159; C:protein phosphatase type 2A complex; IDA:UniProtKB.
 GO:0008601; F:protein phosphatase type 2A regulator activity; IDA:UniProtKB.
 GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; IDA:UniProtKB.
 GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IMP:UniProtKB.
 GO:0008285; P:negative regulation of cell proliferation; IDA:UniProtKB.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:MGI.
 GO:0007165; P:signal transduction; NAS:UniProtKB. 

Interpro

 IPR016024; ARM-type_fold.
 IPR002554; PP2A_B56. 

Pfam

 PF01603; B56 

SMART

  

PROSITE

  

PRINTS