CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014037
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histone acetyltransferase KAT6A 
Protein Synonyms/Alias
 MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; MYST-3; Monocytic leukemia zinc finger homolog; Monocytic leukemia zinc finger protein 
Gene Name
 Kat6a 
Gene Synonyms/Alias
 Moz; Myst3 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
822KSVSRENKDQDSSSLacetylation[1]
1006NSPPVLTKPTLKRKKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2 (By similarity). Acetylates p53/TP53 at 'Lys-120' and 'Lys- 382' and controls its transcriptional activity via association with PML (By similarity). 
Sequence Annotation
 DOMAIN 95 171 H15.
 ZN_FING 199 258 PHD-type 1.
 ZN_FING 255 306 PHD-type 2.
 ZN_FING 536 558 C2HC-type.
 REGION 1 144 Required for activation of RUNX1-1 (By
 REGION 52 166 Required for nuclear localization (By
 REGION 144 662 Interaction with PML (By similarity).
 REGION 312 662 Interaction with RUNX1-1 (By similarity).
 REGION 486 776 Catalytic (By similarity).
 REGION 505 808 Mediates interaction with BRPF1, required
 REGION 643 647 Acetyl-CoA binding (By similarity).
 REGION 652 658 Acetyl-CoA binding (By similarity).
 REGION 1510 1735 Interaction with PML (By similarity).
 REGION 1510 1635 Interaction with RUNX1-2 (By similarity).
 REGION 1907 1942 Required for activation of RUNX1-2 (By
 ACT_SITE 602 602 By similarity.
 ACT_SITE 644 644 Nucleophile (By similarity).
 BINDING 682 682 Acetyl-CoA (By similarity).
 MOD_RES 350 350 N6-acetyllysine (By similarity).
 MOD_RES 355 355 N6-acetyllysine (By similarity).
 MOD_RES 369 369 Phosphothreonine; by PKB/AKT1 (By
 MOD_RES 471 471 Phosphoserine (By similarity).
 MOD_RES 602 602 N6-acetyllysine; by autocatalysis (By
 MOD_RES 900 900 Phosphotyrosine.
 MOD_RES 1006 1006 N6-acetyllysine (By similarity).
 MOD_RES 1114 1114 Phosphoserine (By similarity).  
Keyword
 Acetylation; Activator; Acyltransferase; Chromatin regulator; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1998 AA 
Protein Sequence
MVKLANPLYT QWILEAIKKV KKQKQRPSEE RICNAVSSSH GLDRKTVLEQ LELSVKDGTI 60
LKVSNKGLNS YKDPDNPGRI ALPKPRNHGK LDNKQSVDWN KLLKRAFEGL AESGGSTLKS 120
IERFLKSQKD VSAACGGTAA SGFHQQLRLA IKRAVGHGRL LKDGPLYRLN TKAANAEGKE 180
GCESLSCLPP VSLLPHEKDK PVAEPIPICS FCLGTKEQNR EKKPEDLISC ADCGNSGHPS 240
CLKFSPELTV RVRALRWQCI ECKTCSSCRD QGKNADNMLF CDSCDRGFHM ECCDPPLTRM 300
PKGMWICQIC RPRKKGRKLL QKKAAQIKRR YANPIGRPKN RLKKQSTVSK GPFSKVRTGP 360
GRGRKRKITV SSQSASSSEE GYLERIDGLD FCRDSSAPLK FNKKTKGLID GLTKFFTPSP 420
DGRKARGEAV DYSELRIRKK GNRKSSTSHW PTDNQDGWES KQESEERLFG SQEIMTERDM 480
ELFRDIQEQA LQKVGVTGPP DPQVRCPSVI EFGKYEIHTW YSSPYPQEYS RLPKLYLCEF 540
CLKYMKSRTI LQQHMKKCGW FHPPANEIYR KNNISVFEVD GNVSTIYCQN LCLLAKLFLD 600
HKTLYYDVEP FLFYVLTQND VKGCHLVGYF SKEKHCQQKY NVSCIMILPQ YQRKGYGRFL 660
IDFSYLLSKR EGQAGSPEKP LSDLGRLSYM AYWKSVILEC LYHQNDKQIS IKKLSKLTGV 720
CPQDITSTLH HLRMLDFRSD QFVIIRREKL IQDHMAKLQL NLRPVDVDPE CLRWTPVIVS 780
NSVVSEEEDE EADDGEKEEP QGQERELETR ERVGKSVSRE NKDQDSSSLI ESEKKPEVKE 840
LASSSRLSKQ ALVRDSLPAN SQPPRRGRCG RKNRKTQERF GDKDSKMLVG ETLSTSQEQY 900
GECEEKSAAS RERYTEVGEQ PAAPQAQADG NPDIPKGRFS ESADLWRGQL KKSPETLKCR 960
LPEGNDRLPC CYTDGDRAVF RGFSESSEEE EEPESPRSNS PPVLTKPTLK RKKPILHRRR 1020
RVRKRKHHNS SVVTETISET TEVLDEPFED SDSERPMPRL EPTFEIEEEE EEEDENELFP 1080
RGYFHCLSSQ DILRCQASSK RTASKDEEEE EEESDDADDT PVLKPVSLLR KCDVNSASLE 1140
PDTSTPMKKK KGWPKGKSRK PIHWKKRPGR KPGFKLNQDI IAVSTQECIV EPIVPIKPGR 1200
KPRTQESEEL VEVKEGLVEE RKEEMHTEAD EEAEEEEDAA SSDIRAMSPL DSSNSPDADP 1260
KEPEAEEEEE KPLDDPRQSE EEPQELEEQE QEEEDEVTAE ANQNEDHDAD DEDDGHLDSL 1320
KTKEPEGQPA REDGTEEPGT QESFLDASIQ DSRENAKDKD ETEADSEEEQ PSHEASVGSE 1380
TMPGSEEDHE EDSNTKEELI ELKEEEEIPH SELDLETVQA VQSLTQEESS EHEGAYQDCE 1440
ETLAACQTLQ SYTHTDEDPQ MSMVEDCHAS EHNSPISSIP SHPSQSVRSV SSPSMPALES 1500
GYTQISPEQG SLSAPSMQNM ETSPMMDVPS VSDHSQQVVD SGFSDLGSIE STTENYENPS 1560
SYDSTMGSSI CGNNSSQSSC SYGGLSSSSS LTQNSCVVTQ QMASMGNSCS MLQQNSVQPA 1620
TNCNIKSPQT CVVERPPSNQ QPPPPPPPPP PPQQPQPQPQ QQAAPQPPPP QPQQQPPPPP 1680
QQQPQPPPPP QQQPPLSQCS MNNSFTAAPM IMEIPESGGT GNISIYERIP GDFGAGSYSQ 1740
PSATFSLAKL QQLTNTIMDP HAMPYSHSPA VTSYATSVSL SNTGLAQLAP SHPLAGTPQA 1800
QATMTPPPNL APTTMNLTSP LLQCNMSATN IGIPHTQRLQ GQMPVKGHIS IRSKSAPLPS 1860
ATAHQQQLYG RSPPAVAMQA GPRALAVQRG MNMGVNLMPT PAYNVNSMNM NTLNAMNSYR 1920
MTQPMMNSSY HSNPAYMNQT AQYPMQMQMG MMGSQAYTQQ PMQPNPHGNM MYTGPSHHSY 1980
MNAAGVPKQS LNGPYMRR 1998 
Gene Ontology
 GO:0070776; C:MOZ/MORF histone acetyltransferase complex; ISS:UniProtKB.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0000786; C:nucleosome; IEA:InterPro.
 GO:0016605; C:PML body; ISS:UniProtKB.
 GO:0003677; F:DNA binding; ISS:UniProtKB.
 GO:0004402; F:histone acetyltransferase activity; ISS:UniProtKB.
 GO:0008134; F:transcription factor binding; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; ISS:UniProtKB.
 GO:0090398; P:cellular senescence; ISS:UniProtKB.
 GO:0035162; P:embryonic hemopoiesis; IEA:Compara.
 GO:0043966; P:histone H3 acetylation; ISS:UniProtKB.
 GO:0030099; P:myeloid cell differentiation; ISS:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0006334; P:nucleosome assembly; IEA:InterPro.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0035019; P:somatic stem cell maintenance; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR016181; Acyl_CoA_acyltransferase.
 IPR005818; Histone_H1/H5.
 IPR002717; MOZ_SAS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF01853; MOZ_SAS
 PF00628; PHD 
SMART
 SM00526; H15
 SM00249; PHD
 SM00184; RING 
PROSITE
 PS51504; H15
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 
PRINTS