CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018619
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Retinoid-inducible serine carboxypeptidase 
Protein Synonyms/Alias
 Serine carboxypeptidase 1 
Gene Name
 Scpep1 
Gene Synonyms/Alias
 Risc 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
247AVNKGFYKEATQLWGacetylation[1]
398LSKFNQLKWKALYTDacetylation[1]
400KFNQLKWKALYTDPKacetylation[1]
407KALYTDPKSSETAAFacetylation[1]
443DQGEMALKMMKLVTKacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 May be involved in vascular wall and kidney homeostasis. 
Sequence Annotation
 ACT_SITE 167 167 By similarity.
 ACT_SITE 371 371 By similarity.
 ACT_SITE 431 431 By similarity.
 CARBOHYD 64 64 N-linked (GlcNAc...) (Potential).
 CARBOHYD 102 102 N-linked (GlcNAc...) (Potential).
 CARBOHYD 126 126 N-linked (GlcNAc...) (Potential).
 CARBOHYD 192 192 N-linked (GlcNAc...) (Potential).
 CARBOHYD 362 362 N-linked (GlcNAc...) (Potential).  
Keyword
 Carboxypeptidase; Complete proteome; Glycoprotein; Hydrolase; Protease; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 452 AA 
Protein Sequence
MELSRRICLV RLWLLLLSFL LGFSAGSAID WREPEGKEVW DYVTVRKDAH MFWWLYYATN 60
PCKNFSELPL VMWLQGGPGG SSTGFGNFEE IGPLDTQLKP RNTTWLQWAS LLFVDNPVGT 120
GFSYVNTTDA YAKDLDTVAS DMMVLLKSFF DCHKEFQTVP FYIFSESYGG KMAAGISVEL 180
YKAVQQGTIK CNFSGVALGD SWISPVDSVL SWGPYLYSMS LLDNQGLAEV SDIAEQVLDA 240
VNKGFYKEAT QLWGKAEMII EKNTDGVNFY NILTKSSPEK AMESSLEFLR SPLVRLCQRH 300
VRHLQGDALS QLMNGPIKKK LKIIPEDISW GAQASYVFLS MEGDFMKPAI DVVDKLLAAG 360
VNVTVYNGQL DLIVDTIGQE SWVQKLKWPQ LSKFNQLKWK ALYTDPKSSE TAAFVKSYEN 420
LAFYWILKAG HMVPSDQGEM ALKMMKLVTK QE 452 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0004185; F:serine-type carboxypeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0042573; P:retinoic acid metabolic process; IEA:Compara. 
Interpro
 IPR001563; Peptidase_S10.
 IPR018202; Peptidase_S10_AS. 
Pfam
 PF00450; Peptidase_S10 
SMART
  
PROSITE
 PS00560; CARBOXYPEPT_SER_HIS
 PS00131; CARBOXYPEPT_SER_SER 
PRINTS
 PR00724; CRBOXYPTASEC.