UniProt Accession

 SMYD1_MOUSE; P97443; P97442; P97444; Q6DFW7 

Genbank Protein ID

 U76371; U76373; U76374; AK142252; CH466523; BC076601 

Genbank Nucleotide ID

 AAC53020.1; AAC53021.2; AAC53022.2; BAE24995.1; EDK98934.1; AAH76601.1 

Protein Name

 Histone-lysine N-methyltransferase Smyd1 

Protein Synonyms/Alias

 CD8b-opposite; SET and MYND domain-containing protein 1; Zinc finger protein BOP; m-BOP 

Gene Name

 Smyd1 

Gene Synonyms/Alias

 Bop 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
303	KPSQEVVKEMIQFSK	ubiquitination	[1]
460	QNEFMYHKMREAALN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Methylates histone H3 at 'Lys-4' (H3K4me). Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis. 

Sequence Annotation

 DOMAIN 7 253 SET.
 ZN_FING 52 90 MYND-type.
 METAL 208 208 Zinc.
 METAL 274 274 Zinc.
 METAL 276 276 Zinc.
 METAL 279 279 Zinc.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Methyltransferase; Nucleus; Polymorphism; Reference proteome; Repressor; S-adenosyl-L-methionine; Transcription; Transcription regulation; Transferase; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 490 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
 GO:0003714; F:transcription corepressor activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006338; P:chromatin remodeling; IPI:MGI.
 GO:0007507; P:heart development; IMP:MGI.
 GO:0034968; P:histone lysine methylation; IEA:GOC.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:MGI.
 GO:0045663; P:positive regulation of myoblast differentiation; IEA:Compara.
 GO:0010831; P:positive regulation of myotube differentiation; IEA:Compara.
 GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR001214; SET_dom.
 IPR002893; Znf_MYND. 

Pfam

 PF00856; SET
 PF01753; zf-MYND 

SMART

 SM00317; SET 

PROSITE

 PS50280; SET
 PS01360; ZF_MYND_1
 PS50865; ZF_MYND_2 

PRINTS