CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017281
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family A member 6 
Protein Synonyms/Alias
  
Gene Name
 Abca6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
552LSDMQDLKEIRKAIGacetylation[1]
552LSDMQDLKEIRKAIGubiquitination[2]
556QDLKEIRKAIGVCPQubiquitination[2]
582ENLTLFAKIKGILPQubiquitination[2]
658QRIWGFLKERRADHVubiquitination[2]
683ADILADRKVLIANGAubiquitination[2]
743LKAKTKEKLVYILPLubiquitination[2]
1240RIAPQSLKAQPNPEEubiquitination[2]
1274STPNLDEKPVIIASCubiquitination[2]
1338RMIAGITKPTAGQVEubiquitination[2]
1467QAIQAVVKDNEKGVLubiquitination[2]
1536LVHREILKLFPQAARubiquitination[2]
1616ADMTLGRKLLPPSDEubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Probable transporter which may play a role in macrophage lipid homeostasis (By similarity). 
Sequence Annotation
 DOMAIN 478 713 ABC transporter 1.
 DOMAIN 1282 1520 ABC transporter 2.
 NP_BIND 514 521 ATP 1 (Potential).
 NP_BIND 1320 1327 ATP 2 (Potential).
 CARBOHYD 84 84 N-linked (GlcNAc...) (Potential).
 CARBOHYD 91 91 N-linked (GlcNAc...) (Potential).
 CARBOHYD 576 576 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Glycoprotein; Membrane; Nucleotide-binding; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1624 AA 
Protein Sequence
MKELSVHVRQ QTRALLHKIL LKKWRRKRES LLEWSIPIII GLHMGLFSYL ARNIQVLEVP 60
PQDLGSLNEF NGSSLVVVYT PISNITQQIM NKTTFAPTMK GTRIIGVPSI EDLDEVLLHN 120
IPDALGVIFN DSFSYQLKVL RMYGNPFLKE DLLAHCWDTH SQAFCSLSKY WERGFVALQT 180
AINAGIIEVT TNHSVMEELM SIDGINMKTL PFIPRDLSDY EIFILFCLLY FSSFIYFASS 240
NVTKERKQCK EVMKVMGLQD SAFWLSWGLI YVGFIFIISI FIAIIITSTQ IIMMTGFLVI 300
FTLFFLYGLS LIAVTFLMAV LLQKAVLTNL IVLFFTLFWG CVGFTVLHKE LPPSLEWVLS 360
IFSPFAFTSG MAKVIFQDYN LNGVVFPDPS GESYVMIAVF FILAFDSLLY LVLALYFDKI 420
LLYGAEHRSA PLFFLNPTSC FRKTANRNKV IERDLDPELP SDEYFEPVDP EYQGKEAIRI 480
RNIKKEYKGK SGKVKALKGL FLDIYESQIT AILGHSGAGK SSLLNILSGL YVPTAGSVTV 540
YNKNLSDMQD LKEIRKAIGV CPQHNVQFDA LTVKENLTLF AKIKGILPQD VEQEVQQILS 600
ELDMQNIRDD LAEHLSEGQK RKLTFGIATV GDPQILLLDE PTVGLDPFSR QRIWGFLKER 660
RADHVILFST QFMDEADILA DRKVLIANGA LKCTGSSVFL KRKWGLGYHL SLFMDETCDS 720
ERLTSFINHH IPYAKLKAKT KEKLVYILPL ERTSEFPEFF SDLDKYSGQG LMSYEVSMST 780
LNDVFLNLEG EPSTKQDFEK RETATDSESL NDMEVAYPSL SQVQETVSTM SLWRMQVCAI 840
ARLRILKLKR ERKAFLIILL LLGIALLPLV IEYVANALLE VKNNWEFKTD LYFLSPGQLP 900
QGLRTSLLVI NNTESNIEDF LQSLKHQNIV LEVDDFENRN ATNSLSYNGA IIVSGRQKDY 960
RFSAVCNTKR LHCFPILMNV ISNGILHMLN HTQYIRIKED IFSPFIVLVW TGIQETCLFI 1020
LCVICSLSPH IAMSSVSDYK KKADSQLWIS GLYPSAYWCG QAVVDISLFS GMLLTSYFTS 1080
YTSKLLNIDM TSEIVFSVIV LALGCAASLV FLTYVISFVF GKRKKNSTLW SICFLLVIAI 1140
TFEKVANGPF NEALVISATM LVPSFALNGL LVVLEMRAYQ YYIEFEEIKH GLSAVDLLLC 1200
LIPYIHTLLF IFVLRCLELK YGKNVVRRDP IFRIAPQSLK AQPNPEEPID EDENVQAERL 1260
RTSDALSTPN LDEKPVIIAS CLHKEYAGQK KHCCSRRTRN MAVRNVSFCV NKGEILGLLG 1320
PDGAGKSSSI RMIAGITKPT AGQVELKRLS SAVGHQGDSR AEFGYCPQEN GLWPNLTVKE 1380
HLELYAAVKG LRKEDAVVAI SRLVNALKLH DQLNVQVQNL VAGATRKLCF VLSILGNSPV 1440
LILDEPSTGL DVSGKHQVWQ AIQAVVKDNE KGVLLSTHDL AEAEALCDRA AIMVSGRLRC 1500
IGPIQHLKRK FGQDYVLELR VKDVSQEPLV HREILKLFPQ AARQDRCFSL LTYKLPVTDV 1560
HPLSQAFHKL EAVKHGFDLE DYSLSQCTLD RVILELSKEQ ELGTVYEEAD MTLGRKLLPP 1620
SDEL 1624 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR026082; ABC_A.
 IPR003439; ABC_transporter-like.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS