Tag | Content |
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CPLM ID | CPLM-014845 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | General transcription factor IIF subunit 1 |
Protein Synonyms/Alias | Transcription initiation factor IIF subunit alpha; TFIIF-alpha |
Gene Name | Gtf2f1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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114 | GRKFKGIKKGGVTEN | acetylation | [1] | 200 | EKEKRSRKKPSELRI | acetylation | [1] | 407 | TLRAAASKLEQGKRT | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation (By similarity). |
Sequence Annotation | MOD_RES 2 2 N-acetylalanine (By similarity). MOD_RES 217 217 Phosphoserine (By similarity). MOD_RES 218 218 Phosphoserine (By similarity). MOD_RES 221 221 Phosphoserine (By similarity). MOD_RES 224 224 Phosphoserine (By similarity). MOD_RES 331 331 Phosphothreonine (By similarity). MOD_RES 377 377 Phosphoserine (By similarity). MOD_RES 380 380 Phosphoserine (By similarity). MOD_RES 381 381 Phosphoserine (By similarity). MOD_RES 385 385 Phosphoserine (By similarity). MOD_RES 389 389 Phosphothreonine (By similarity). MOD_RES 391 391 Phosphoserine (By similarity). MOD_RES 407 407 N6-acetyllysine (By similarity). MOD_RES 431 431 Phosphoserine (By similarity). MOD_RES 433 433 Phosphoserine (By similarity). MOD_RES 436 436 Phosphoserine (By similarity). MOD_RES 437 437 Phosphothreonine (By similarity). MOD_RES 440 440 Phosphoserine (By similarity). |
Keyword | Acetylation; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 508 AA |
Protein Sequence | MAALGSSSQN VTEYVVRVPK NTAKRYNIMA FNAADKVNFA TWNQARLERD LSNKKIYQEE 60 EMPESGAGSE FNRKLREEAR RKKYGIVLKE FRPEDQPWLL RVNGKSGRKF KGIKKGGVTE 120 NTAYYIFTQC ADGAFEAFPV QNWYNFTPLA RHRTLTAEEA EEEWERRNKV LNHFSIMQQR 180 RLKDQDQDED EEEKEKRSRK KPSELRIHDL EDDLEMSSDA SDASGEEGSR ASKAKKKAPV 240 TKAGRKKKKK KGSDDEAFED SDDGDFEGQE VDYMSDGSSS SPDEAEGKPK VPQQEDGPKG 300 VDEQSESSEE SEEEKPPEED KEEEEEKKAP TPQEKKRRKD SSDDSDSSEE SDIDSETSSA 360 LFMAKKKTPP KRERKPSGGS SKGTSRPGTP SAEAASTSST LRAAASKLEQ GKRTSETPAA 420 KRLRMDTGPQ SLSGKSTPSS GDVQVTEDAV RRYLTRKPMT TKDLLKKFQT KKTGLSSEQT 480 VNVLAQILKR LNPERKMIGD KMHFSLKE 508 |
Gene Ontology | GO:0030054; C:cell junction; IEA:Compara. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003824; F:catalytic activity; IEA:InterPro. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0019211; F:phosphatase activator activity; IEA:Compara. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0009615; P:response to virus; IEA:Compara. GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |