UniProt Accession

 LHP1_YEAST; P33399; D6VRU5 

Genbank Protein ID

 L33023; Z74099; AY558373; L13282; X80801; BK006938 

Genbank Nucleotide ID

 AAA21777.1; CAA98612.1; AAS56699.1; AAA16515.1; CAA56782.1; DAA11805.1 

Protein Name

 La protein homolog 

Protein Synonyms/Alias

 La autoantigen homolog; La ribonucleoprotein 

Gene Name

 LHP1 

Gene Synonyms/Alias

 LAH1; YLA1; YDL051W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
82	KKYRPVDKVIEALRS	acetylation	[1]
153	NLEAFFKKLGEINQV	ubiquitination	[2]
215	KLSVLTKKQFDLQRE	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Molecular chaperone that binds nascent RNA polymerase III transcripts, stabilizing these RNAs against exonucleases. Required for the 3' endonucleolytic cleavage that matures tRNA precursors and for efficient folding of certain pre-tRNAs. Cooperaes with GCD14 in the maturation of a subset of RNA polymerase III transcripts. Functions also in the assembly of certain RNA polymerase II-transcribed RNAs into RNPs. Binds and stabilizes newly synthesized U6 snRNA as well as precursors of U3 snRNA from degradation. Facilitates efficient Sm protein binding, thus assisting formation of the U4/U6 snRNP. Required fot Ty3 normal transposition frequency. 

Sequence Annotation

 DOMAIN 23 112 HTH La-type RNA-binding.
 DOMAIN 123 216 RRM.
 MOTIF 240 256 Nuclear localization signal (Potential).
 MOD_RES 15 15 Phosphoserine.
 MOD_RES 19 19 Phosphoserine.
 MOD_RES 230 230 Phosphoserine.
 MOD_RES 235 235 Phosphoserine.  

Keyword

 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 275 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0005654; C:nucleoplasm; IDA:SGD.
 GO:0030529; C:ribonucleoprotein complex; IEA:InterPro.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0000049; F:tRNA binding; IDA:SGD.
 GO:0008033; P:tRNA processing; IMP:SGD. 

Interpro

 IPR002344; Lupus_La.
 IPR006630; Lupus_La_RNA-bd.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF05383; La
 PF00076; RRM_1 

SMART

 SM00715; LA
 SM00360; RRM 

PROSITE

 PS50961; HTH_LA
 PS50102; RRM 

PRINTS

 PR00302; LUPUSLA.