CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023366
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable cytochrome P450 12a5, mitochondrial 
Protein Synonyms/Alias
 CYPXIIA5 
Gene Name
 Cyp12a5 
Gene Synonyms/Alias
 CG11821 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
169NPVLMQPKNVRLYFKacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702
Functional Description
  
Sequence Annotation
 METAL 482 482 Iron (heme axial ligand) (By similarity).  
Keyword
 Complete proteome; Heme; Iron; Membrane; Metal-binding; Mitochondrion; Monooxygenase; Oxidoreductase; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 536 AA 
Protein Sequence
MLKGRIALNI LQSQKPIVFS ASQQRWQTNV PTAEIRNDPE WLQAKPFEEI PKANILSLFA 60
KSALPGGKYK NLEMMEMIDA LRQDYGNIIF LPGMMGRDGL VMTHNPKDFE VVFRNEGVWP 120
FRPGSDILRY HRTVYRKDFF DGVQGIIPSQ GKSWGDFRSI VNPVLMQPKN VRLYFKKMSQ 180
VNQEFVELIK EIRDASTQEV PGNFLETINR WTLESVSVVA LDKQLGLLRE SGKNSEATKL 240
FKYLDEFFLH SADLEMKPSL WRYFKTPLLK KMLRTMDSVQ EVTLKYVDEA IERLEKEAKE 300
GVVRPEHEQS VLEKLLKVDK KVATVMAMDM LMAGVDTTSS TFTALLLCLA KNPEKQARLR 360
EEVMKVLPNK DSEFTEASMK NVPYLRACIK ESQRVYPLVI GNARGLTRDS VISGYRVPAG 420
TIVSMIPINS LYSEEYFPKP TEFLPERWLR NASDSAGKCP ANDLKTKNPF VFLPFGFGPR 480
MCVGKRIVEM ELELGTARLI RNFNVEFNHS TKNAFRSALI NLPNIPLKFK FTDVPN 536 
Gene Ontology
 GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
 GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR00385; P450.