CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014887
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleolar protein 58 
Protein Synonyms/Alias
 MSSP; Nucleolar protein 5; SIK-similar protein 
Gene Name
 Nop58 
Gene Synonyms/Alias
 Nol5 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
206SDNLTYCKCLQKVGDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Required for 60S ribosomal subunit biogenesis (By similarity). 
Sequence Annotation
 DOMAIN 282 400 Nop.
 MOD_RES 109 109 Phosphoserine (By similarity).
 MOD_RES 351 351 Phosphoserine (By similarity).
 MOD_RES 509 509 Phosphoserine.
 MOD_RES 521 521 Phosphoserine.
 CROSSLNK 467 467 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 504 504 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Complete proteome; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Ribosome biogenesis; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 536 AA 
Protein Sequence
MLVLFETSVG YAIFKVLNEK KLQEVDSLWK EFETPEKANK IVKLKHFEKF QDTAEALAAF 60
TALMEGKINK QLKKVLKKIV KEAHEPLAVA DAKLGGVIKE KLNLSCIHSP VVNELMRGIR 120
SQMDGLIPGV EPREMAAMCL GLAHSLSRYR LKFSADKVDT MIVQAISLLD DLDKELNNYI 180
MRCREWYGWH FPELGKIISD NLTYCKCLQK VGDRKNYASA SLSEFLSEEV EAEVKAAAEI 240
SMGTEVSEED ICNILHLCTQ VIEISEYRTQ LYEYLQNRMM AIAPNVTVMV GELVGARLIA 300
HAGSLLNLAK HAASTVQILG AEKALFRALK SRRDTPKYGL IYHASLVGQS SPKHKGKISR 360
MLAAKTVLAI RYDAFGEDSS SAMGIENRAK LEARLRILED RGIRKISGTG KALAKAEKYE 420
HKSEVKTYDP SGDSTLPTCS KKRKIEEVDK EDEITEKKAK KAKIKIKAEV EEEMEEEEAE 480
EEQVVEEEPT VKKKKKKDKK KHIKEEPLSE EEPCTSTAVP SPEKKKKKKK KKDAED 536 
Gene Ontology
 GO:0015030; C:Cajal body; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005730; C:nucleolus; IC:MGI.
 GO:0070761; C:pre-snoRNP complex; IEA:Compara.
 GO:0005732; C:small nucleolar ribonucleoprotein complex; IEA:Compara.
 GO:0030515; F:snoRNA binding; IEA:Compara.
 GO:0030519; F:snoRNP binding; ISO:MGI.
 GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
 GO:0006608; P:snRNP protein import into nucleus; IEA:Compara. 
Interpro
 IPR012974; NOP5_N.
 IPR002687; Nop_dom.
 IPR012976; NOSIC. 
Pfam
 PF01798; Nop
 PF08156; NOP5NT
 PF08060; NOSIC 
SMART
 SM00931; NOSIC 
PROSITE
 PS51358; NOP 
PRINTS