CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029911
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Myh13 
Protein Synonyms/Alias
  
Gene Name
 Myh13 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
272IETYLLEKSRVTFQLubiquitination[1]
365VMHYGNMKFKQKQREubiquitination[1]
369GNMKFKQKQREEQAEubiquitination[1]
407GLCCPRVKVGNEYVTubiquitination[1]
452INQQLDTKQPRQYFIubiquitination[1]
504VLEQEEYKKEGIEWEubiquitination[1]
567GKSNNFQKPKPTKGKubiquitination[1]
600AGWLDKNKDPLNETVubiquitination[1]
613TVVGLYQKSSLKLLSubiquitination[1]
723RILYADFKQRYRILNubiquitination[1]
880RRKELEEKMVSLLQEubiquitination[1]
922SKIQLEAKVKELNERubiquitination[1]
1330LEEETKAKNALAHALubiquitination[1]
1367ELQRALSKANSEVAQubiquitination[1]
1378EVAQWRTKYETDAIQacetylation[2]
1378EVAQWRTKYETDAIQubiquitination[1]
1394TEELEEAKKKLAQRLubiquitination[1]
1420SKCASLEKTKQRLQGubiquitination[1]
1455KKQRNFDKVLAEWKQubiquitination[1]
1795KNLEQTVKDLQHRLDubiquitination[1]
1810EAEQLALKGGKKQIQubiquitination[1]
1813QLALKGGKKQIQKLEubiquitination[1]
1814LALKGGKKQIQKLEAubiquitination[1]
1874RLQDLVDKLQAKVKSubiquitination[1]
1878LVDKLQAKVKSYKRQubiquitination[1]
1923IAESQVNKLRAKSRDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; ATP-binding; Coiled coil; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1938 AA 
Protein Sequence
MSSDAEMAIF GEAAPYLRKP EKERIEAQNR PFDSKKACFA VDDKEMYVKG MIQSRENDKV 60
IVKTLDDREL TLNSDQVFPM NPPKFDKIED MAMMTHLHEP AVLYNLKERY AAWMIYTYSG 120
LFCVTVNPYK WLPVYNPEVV AAYRGKKRQE APPHIFSISD NAYQFMLTDR DNQSILITGE 180
SGAGKTVNTK RVIQYFATIA VTGDKKKEQQ PGKMQGTLED QIIQANPLLE AFGNAKTVRN 240
DNSSRFGKFI RIHFGATGKL ASADIETYLL EKSRVTFQLS SERSYHIFYQ IMSNKKPELI 300
DLLLISTNPF DFPFVSQGEV TVASIDDSEE LLATDNAIDI LGFSPEEKVG IYKLTGAVMH 360
YGNMKFKQKQ REEQAEPDGT EVADKAGYLM GLNSAEMLKG LCCPRVKVGN EYVTKGQNVQ 420
QVTNSVGALA KAVYEKMFLW MVTRINQQLD TKQPRQYFIG VLDIAGFEIF DFNSLEQLCI 480
NFTNEKLQQF FNHHMFVLEQ EEYKKEGIEW EFIDFGMDLA ACIELIEKPM GIFSILEEEC 540
MFPKATDTSF KNKLYDQHLG KSNNFQKPKP TKGKAEAHFS LVHYAGTVDY NIAGWLDKNK 600
DPLNETVVGL YQKSSLKLLS FLFSNYAGAE AGDSAGGKKG GKKKGSSFQT VSAVFRENLN 660
KLMTNLRSTH PHFVRCLIPN ETKTPGVMDH YLVMHQLRCN GVLEGIRICR KGFPSRILYA 720
DFKQRYRILN ASAIPEGQFI DSKNASEKLL NSIDVDREQF RFGHTKVFFK AGLLGLLEEM 780
RDEKLVTLMT RTQAVCRGYL MRVEFKKMME RRESIFCIQY NVRSFMNVKH WPWMNLFFKI 840
KPLLKSAEAE KEMATMKEDF ERAKEDLARS EARRKELEEK MVSLLQEKND LQLQVQSETE 900
NLMDAEERCE GLIKSKIQLE AKVKELNERL EEEEEMNSEL VAKKRNLEDK CSSLKRDIDD 960
LELTLTKVEK EKHATENKVK NLSEEMTALE ETISKLTKEK KSLQEAHQQT LDDLQVEEDK 1020
VNGLIKINVK LEQQTDDLEG SLEQEKKLRA DLERVKRKLE GDLKMSQESI MDLENDTQQL 1080
EEKLKKKEFE MSQLQTRIDD EQVLSLQLQK KIKELQARTE ELEEEIEAEH TVRAKIEKQR 1140
SDLARELEEI SERLEEASGA TSAQIEMNKK RESEFQKLRR DLEEATLQHE ATAATLRKKH 1200
ADTVAELGEQ IDNLQRVKQK LEKEKSELKM EIDDMASNIE TVSKSKSNME RMCRSVEDQF 1260
NEIKAKDDQQ TQLIHDLNMQ KARLQTQNGE LSHQVEEKES LVSQLTKSKQ ALTQQLEELK 1320
RQLEEETKAK NALAHALQSS RHDCDLLREQ YEEEQEGKAE LQRALSKANS EVAQWRTKYE 1380
TDAIQRTEEL EEAKKKLAQR LQEAEENTEA SNSKCASLEK TKQRLQGEVD DLMLDLERAN 1440
TACATLDKKQ RNFDKVLAEW KQKLDESQAE LEAAQKESRS LSTEIFKMRN AYEEVVDQLE 1500
TLRRENKNLQ EEISDLTEQI AETGKNLQEV EKTKKQVEQE KSDLQAALEE VEGSLEHEES 1560
KILRVQLELS QVKSELDRKV TEKDEEIEQI KRNSQRAVEA MQSVLDAEIR SRNDALRLKK 1620
KMEGDLNEME IQLSHANRQV AETQKHLRTV QGQLKDSQLH LDDAQRSNED LKEQLAIVER 1680
RNGLLQEELE EMKVALEQTE RTRRLSEQEL LDSSDRVQLL HSQNTSLINT KKKLEADLAQ 1740
CQAEVENSIQ ESRNAEEKAK KAITDAAMMA EELKKEQDTS AHLERMKKNL EQTVKDLQHR 1800
LDEAEQLALK GGKKQIQKLE ARVRELESEL DAEQKRGAEA LKGAHKYERK VKEMTYQAEE 1860
DRKNILRLQD LVDKLQAKVK SYKRQAEEAE EQANTQLSRC RRVQHELEEA EERADIAESQ 1920
VNKLRAKSRD VGGQKMEE 1938 
Gene Ontology
 GO:0030016; C:myofibril; IDA:MGI.
 GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro.
 GO:0009267; P:cellular response to starvation; IDA:MGI. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR015650; Myosin_1/23/4/7/8/13/15.
 IPR001609; Myosin_head_motor_dom.
 IPR004009; Myosin_N.
 IPR002928; Myosin_tail.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00063; Myosin_head
 PF02736; Myosin_N
 PF01576; Myosin_tail_1 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.