UniProt Accession

 FBX2_MOUSE; Q80UW2; Q8R0D2 

Genbank Protein ID

 BC027053; BC046586 

Genbank Nucleotide ID

 AAH27053.1; AAH46586.1 

Protein Name

 F-box only protein 2 

Protein Synonyms/Alias

  

Gene Name

 Fbxo2 

Gene Synonyms/Alias

 Fbs1; Fbx2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
83	RLVCLRWKELVDGAP	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type. 

Sequence Annotation

 DOMAIN 48 95 F-box.
 DOMAIN 117 297 FBA.
 REGION 214 216 Carbohydrate binding.
 REGION 279 280 Carbohydrate binding.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Endoplasmic reticulum; Lectin; Membrane; Microsome; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 297 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0043197; C:dendritic spine; IDA:MGI.
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
 GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell.
 GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB.
 GO:0001540; F:beta-amyloid binding; IDA:MGI.
 GO:0030246; F:carbohydrate binding; IDA:MGI.
 GO:0001948; F:glycoprotein binding; IDA:MGI.
 GO:0030433; P:ER-associated protein catabolic process; IDA:MGI.
 GO:0006516; P:glycoprotein catabolic process; IDA:UniProtKB.
 GO:0016567; P:protein ubiquitination; IDA:UniProtKB.
 GO:0031396; P:regulation of protein ubiquitination; IDA:MGI.
 GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IDA:UniProtKB. 

Interpro

 IPR007397; F-box-assoc_dom.
 IPR001810; F-box_dom_cyclin-like.
 IPR008979; Galactose-bd-like. 

Pfam

 PF00646; F-box
 PF04300; FBA 

SMART

  

PROSITE

 PS51114; FBA
 PS50181; FBOX 

PRINTS