UniProt Accession

 SUCD_ECOLI; P0AGE9; P07459 

Genbank Protein ID

 J01619; U00096; AP009048; X15790 

Genbank Nucleotide ID

 AAA23900.1; AAC73823.1; BAA35395.1; CAA33792.1 

Protein Name

 Succinyl-CoA ligase [ADP-forming] subunit alpha 

Protein Synonyms/Alias

 Succinyl-CoA synthetase subunit alpha; SCS-alpha 

Gene Name

 sucD 

Gene Synonyms/Alias

 b0729; JW0718 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
7	*MSILIDKNTKVICQ	acetylation	[1]
10	ILIDKNTKVICQGFT	acetylation	[2, 3]
34	QAIAYGTKMVGGVTP	acetylation	[2, 3]
43	VGGVTPGKGGTTHLG	acetylation	[2]
111	DMLTVKVKLDEAGVR	acetylation	[3]
228	YIKEHVTKPVVGYIA	acetylation	[3]
241	IAGVTAPKGKRMGHA	acetylation	[3]
262	GKGTADEKFAALEAA	acetylation	[3]
272	ALEAAGVKTVRSLAD	acetylation	[3]
285	ADIGEALKTVLK***	acetylation	[2, 3]

Reference

 [1] The diversity of lysine-acetylated proteins in Escherichia coli.
 Yu BJ, Kim JA, Moon JH, Ryu SE, Pan JG.
 J Microbiol Biotechnol. 2008 Sep;18(9):1529-36. [PMID: 18852508]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [3] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

  

Sequence Annotation

 ACT_SITE 247 247 Tele-phosphohistidine intermediate.  

Keyword

 3D-structure; ATP-binding; Complete proteome; Direct protein sequencing; Ligase; Nucleotide-binding; Phosphoprotein; Reference proteome; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 289 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003878; F:ATP citrate synthase activity; IEA:InterPro.
 GO:0048037; F:cofactor binding; IEA:InterPro.
 GO:0004775; F:succinate-CoA ligase (ADP-forming) activity; IEA:EC.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. 

Interpro

 IPR017440; Cit_synth/succinyl-CoA_lig_AS.
 IPR003781; CoA-bd.
 IPR005810; CoA_lig_alpha.
 IPR005811; CoA_ligase.
 IPR016040; NAD(P)-bd_dom.
 IPR016102; Succinyl-CoA_synth-like. 

Pfam

 PF02629; CoA_binding
 PF00549; Ligase_CoA 

SMART

 SM00881; CoA_binding 

PROSITE

 PS01216; SUCCINYL_COA_LIG_1
 PS00399; SUCCINYL_COA_LIG_2 

PRINTS

 PR01798; SCOASYNTHASE.