CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028662
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Glutamate receptor ionotropic, NMDA 1 
Protein Synonyms/Alias
  
Gene Name
 Grin1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
876RGALQNQKDTVLPRRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Cell junction; Cell membrane; Complete proteome; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor; Reference proteome; Synapse; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 901 AA 
Protein Sequence
MSTMHLLTFA LLFSCSFARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN KRHGSWKIQL 60
NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND HFTPTPVSYT AGFYRIPVLG 120
LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV WFEMMRVYNW NHIILLVSDD HEGRAAQKRL 180
ETLLEERESK AEKVLQFDPG TKNVTALLME ARDLEARVII LSASEDDAAT VYRAAAMLNM 240
TGSGYVWLVG EREISGNALR YAPDGIIGLQ LINGKNESAH ISDAVGVVAQ AVHELLEKEN 300
ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY ADGVTGRVEF NEDGDRKFAN YSIMNLQNRK 360
LVQVGIYNGT HVIPNDRKII WPGGETEKPR GYQMSTRLKI VTIHQEPFVY VKPTMSDGTC 420
KEEFTVNGDP VKKVICTGPN DTSPGSPRHT VPQCCYGFCV DLLIKLARTM NFTYEVHLVA 480
DGKFGTQERV NNSNKKEWNG MMGELLSGQA DMIVAPLTIN NERAQYIEFS KPFKYQGLTI 540
LVKKEIPRST LDSFMQPFQS TLWLLVGLSV HVVAVMLYLL DRFSPFGRFK VNSEEEEEDA 600
LTLSSAMWFS WGVLLNSGIG EGAPRSFSAR ILGMVWAGFA MIIVASYTAN LAAFLVLDRP 660
EERITGINDP RLRNPSDKFI YATVKQSSVD IYFRRQVELS TMYRHMEKHN YESAAEAIQA 720
VRDNKLHAFI WDSAVLEFEA SQKCDLVTTG ELFFRSGFGI GMRKDSPWKQ NVSLSILKSH 780
ENGFMEDLDK TWVRYQECDS RSNAPATLTF ENMAGVFMLV AGGIVAGIFL IFIEIAYKRH 840
KDARRKQMQL AFAAVNVWRK NLQSTGGGRG ALQNQKDTVL PRRAIEREEG QLQLCSRHRE 900
S 901 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0017146; C:N-methyl-D-aspartate selective glutamate receptor complex; IPI:MGI.
 GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
 GO:0014069; C:postsynaptic density; IDA:MGI.
 GO:0045211; C:postsynaptic membrane; IDA:MGI.
 GO:0008021; C:synaptic vesicle; IDA:MGI.
 GO:0005262; F:calcium channel activity; IDA:MGI.
 GO:0005509; F:calcium ion binding; IDA:MGI.
 GO:0005516; F:calmodulin binding; IDA:MGI.
 GO:0005234; F:extracellular-glutamate-gated ion channel activity; IEA:InterPro.
 GO:0004972; F:N-methyl-D-aspartate selective glutamate receptor activity; IDA:MGI.
 GO:0008344; P:adult locomotory behavior; IMP:MGI.
 GO:0006874; P:cellular calcium ion homeostasis; IMP:MGI.
 GO:0021987; P:cerebral cortex development; IMP:MGI.
 GO:0001661; P:conditioned taste aversion; IMP:MGI.
 GO:0007616; P:long-term memory; IMP:MGI.
 GO:0060179; P:male mating behavior; IMP:MGI.
 GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.
 GO:0008355; P:olfactory learning; IMP:MGI.
 GO:0021586; P:pons maturation; IMP:MGI.
 GO:0043065; P:positive regulation of apoptotic process; IGI:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0060134; P:prepulse inhibition; IMP:MGI.
 GO:0050770; P:regulation of axonogenesis; IMP:MGI.
 GO:0048814; P:regulation of dendrite morphogenesis; IMP:MGI.
 GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IMP:MGI.
 GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI.
 GO:0043576; P:regulation of respiratory gaseous exchange; IMP:MGI.
 GO:0051963; P:regulation of synapse assembly; IMP:MGI.
 GO:0007585; P:respiratory gaseous exchange; IMP:MGI.
 GO:0001975; P:response to amphetamine; IMP:MGI.
 GO:0043278; P:response to morphine; IMP:MGI.
 GO:0019233; P:sensory perception of pain; IMP:MGI.
 GO:0035176; P:social behavior; IMP:MGI.
 GO:0001967; P:suckling behavior; IMP:MGI.
 GO:0035249; P:synaptic transmission, glutamatergic; IMP:MGI.
 GO:0008542; P:visual learning; IMP:MGI. 
Interpro
 IPR001828; ANF_lig-bd_rcpt.
 IPR018882; CaM-bd_C0_NMDA_rcpt_NR1.
 IPR019594; Glu_rcpt_Glu/Gly-bd.
 IPR001320; Iontro_glu_rcpt.
 IPR001508; NMDA_rcpt.
 IPR001638; SBP_bac_3. 
Pfam
 PF01094; ANF_receptor
 PF10562; CaM_bdg_C0
 PF00060; Lig_chan
 PF00497; SBP_bac_3 
SMART
 SM00918; Lig_chan-Glu_bd
 SM00079; PBPe 
PROSITE
  
PRINTS
 PR00177; NMDARECEPTOR.