UniProt Accession

 NANP_HUMAN; Q8TBE9; B3KP12; Q5JYN8; Q8TE97; Q9Y3N0 

Genbank Protein ID

 AK055472; AK074335; AL031673; CH471133; BC022552 

Genbank Nucleotide ID

 BAG51524.1; BAB85055.1; CAI22444.1; EAX10081.1; AAH22552.1 

Protein Name

 N-acylneuraminate-9-phosphatase 

Protein Synonyms/Alias

 Haloacid dehalogenase-like hydrolase domain-containing protein 4; Neu5Ac-9-Pase 

Gene Name

 NANP 

Gene Synonyms/Alias

 C20orf147; HDHD4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
84	EEAIQETKGGAANRK	ubiquitination	[1]
211	KATVWINKNGIVPLK	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

 REGION 12 14 Substrate binding.
 REGION 131 132 Substrate binding.
 BINDING 164 164 Substrate.  

Keyword

 3D-structure; Carbohydrate metabolism; Complete proteome; Hydrolase; Magnesium; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 248 AA 

Protein Sequence

Gene Ontology

 GO:0050124; F:N-acylneuraminate-9-phosphatase activity; IDA:UniProtKB.
 GO:0008967; F:phosphoglycolate phosphatase activity; IEA:InterPro.
 GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
 GO:0006045; P:N-acetylglucosamine biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0046380; P:N-acetylneuraminate biosynthetic process; IDA:UniProtKB. 

Interpro

 IPR023214; HAD-like_dom.
 IPR011950; HAD-SF_hydro_IA_CTE7.
 IPR006439; HAD-SF_hydro_IA_v1.
 IPR005833; Haloacid_DH/epoxide_hydro. 

Pfam

 PF13419; HAD_2 

SMART

  

PROSITE

  

PRINTS

 PR00413; HADHALOGNASE.