CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016749
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Methylmalonic aciduria type A homolog, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Mmaa 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
78HTEGLSDKEQRFVDRacetylation[1, 2, 3]
137QELRNQGKPLTFRVGacetylation[1]
409RAADLLLKAFKSRH*acetylation[1]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
 Probable GTPase. May function as chaperone. May be involved in the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis (By similarity). 
Sequence Annotation
 NP_BIND 147 155 GTP (By similarity).
 NP_BIND 325 327 GTP (By similarity).
 BINDING 289 289 GTP (By similarity).  
Keyword
 Chaperone; Complete proteome; GTP-binding; Hydrolase; Mitochondrion; Nucleotide-binding; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 415 AA 
Protein Sequence
MTISTLLLSP NRRLLTCLSR VPSPWLLHSS HPAPGPPGAL PNCFGHHCTK RVLLSDGFRR 60
TLCVQATLKD HTEGLSDKEQ RFVDRLYTGL VKGQRACLAE AITLVESTHT RKRELAQVLL 120
QRVLALQREQ ELRNQGKPLT FRVGLSGPPG AGKSTFIECF GKMLTEQGHR LSVLAVDPSS 180
CTSGGSLLGD KTRMIELSRD MNAYIRPSPT SGTLGGVTRT TNEAIVLCEG GGYDIILIET 240
VGVGQSEFAV ADMVDMFVLL LPPAGGDELQ GIKRGIIEMA DLVVITKSDG DLIVPARRIQ 300
AEYVSALKLL RRRSEVWRPK VIRISARSGE GITEMWDTMR EFQHQMLASG ELAAKRQTQH 360
KVWMWNLIQE NVLEHFKTHP SIREQIPLME RKVLSGALSP GRAADLLLKA FKSRH 415 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
 GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR005129; ArgK.
 IPR027417; P-loop_NTPase. 
Pfam
 PF03308; ArgK 
SMART
 SM00382; AAA 
PROSITE
  
PRINTS