CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027108
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytosine-specific methyltransferase 
Protein Synonyms/Alias
  
Gene Name
 Dnmt1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
676CQQPECGKCKACKDMubiquitination[1]
681CGKCKACKDMVKFGGubiquitination[1]
992RKYSDYIKGSNLDAPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Methyltransferase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1627 AA 
Protein Sequence
MPARTAPARV PALASPAGSL PDHVRRRLKD LERDGLTEKE CVREKLNLLH EFLQTEIKSQ 60
LCDLETKLHK EELSEEGYLA KVKSLLNKDL SLENGTHTLT QKANGCPANG SRPTWRAEMA 120
DSNRSPRSRP KPRGPRRSKS DSDTLCKDTR HTAVETSPSS VATRRTTRQT TITAHFTKGP 180
TKRKPKEESE EGNSAESAAE ERDQDKKRRV VDTESGAAAA VEKLEEVTAG TQLGPEEPCE 240
QEDDNRSLRR HTRELSLRRK SKEDPDREAR PETHLDEDED GKKDKRSSRP RSQPRDPAAK 300
RRPKEAEPEQ VAPETPEDRD EDEREEKRRK TTRKKLESHT VPVQSRSERK AAQSKSVIPK 360
INSPKCPECG QHLDDPNLKY QQHPEDAVDE PQMLTSEKLS IYDSTSTWFD TYEDSPMHRF 420
TSFSVYCSRG HLCPVDTGLI EKNVELYFSG CAKAIHDENP SMEGGINGKN LGPINQWWLS 480
GFDGGEKVLI GFSTAFAEYI LMEPSKEYEP IFGLMQEKIY ISKIVVEFLQ NNPDAVYEDL 540
INKIETTVPP STINVNRFTE DSLLRHAQFV VSQVESYDEA KDDDETPIFL SPCMRALIHL 600
AGVSLGQRRA TRRVMGATKE KDKAPTKATT TKLVYQIFDT FFSEQIEKYD KEDKENAMKR 660
RRCGVCEVCQ QPECGKCKAC KDMVKFGGTG RSKQACLKRR CPNLAVKEAD DDEEADDDVS 720
EMPSPKKLHQ GKKKKQNKDR ISWLGQPMKI EENRTYYQKV SIDEEMLEVG DCVSVIPDDS 780
SKPLYLARVT ALWEDKNGQM MFHAHWFCAG TDTVLGATSD PLELFLVGEC ENMQLSYIHS 840
KVKVIYKAPS ENWAMEGGTD PETTLPGAED GKTYFFQLWY NQEYARFESP PKTQPTEDNK 900
HKFCLSCIRL AELRQKEMPK VLEQIEEVDG RVYCSSITKN GVVYRLGDSV YLPPEAFTFN 960
IKVASPVKRP KKDPVNETLY PEHYRKYSDY IKGSNLDAPE PYRIGRIKEI HCGKKKGKVN 1020
EADIKLRLYK FYRPENTHRS YNGSYHTDIN MLYWSDEEAV VNFSDVQGRC TVEYGEDLLE 1080
SIQDYSQGGP DRFYFLEAYN SKTKNFEDPP NHARSPGNKG KGKGKGKGKG KHQVSEPKEP 1140
EAAIKLPKLR TLDVFSGCGG LSEGFHQAGI SETLWAIEMW DPAAQAFRLN NPGTTVFTED 1200
CNVLLKLVMA GEVTNSLGQR LPQKGDVEML CGGPPCQGFS GMNRFNSRTY SKFKNSLVVS 1260
FLSYCDYYRP RFFLLENVRN FVSYRRSMVL KLTLRCLVRM GYQCTFGVLQ AGQYGVAQTR 1320
RRAIILAAAP GEKLPLFPEP LHVFAPRACQ LSVVVDDKKF VSNITRLSSG PFRTITVRDT 1380
MSDLPEIQNG ASNSEIPYNG EPLSWFQRQL RGSHYQPILR DHICKDMSPL VAARMRHIPL 1440
FPGSDWRDLP NIQVRLGDGV IAHKLQYTFH DVKNGYSSTG ALRGVCSCAE GKACDPESRQ 1500
FSTLIPWCLP HTGNRHNHWA GLYGRLEWDG FFSTTVTNPE PMGKQGRVLH PEQHRVVSVR 1560
ECARSQGFPD SYRFFGNILD RHRQVGNAVP PPLAKAIGLE IKLCLLSSAR ESASAAVKAK 1620
EEAATKD 1627 
Gene Ontology
 GO:0000792; C:heterochromatin; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005657; C:replication fork; IDA:MGI.
 GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IDA:MGI.
 GO:0008327; F:methyl-CpG binding; IDA:MGI.
 GO:0003723; F:RNA binding; IDA:MGI.
 GO:0008270; F:zinc ion binding; IDA:MGI.
 GO:0071230; P:cellular response to amino acid stimulus; IDA:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0042127; P:regulation of cell proliferation; IGI:MGI. 
Interpro
 IPR001025; BAH_dom.
 IPR018117; C5_DNA_meth_AS.
 IPR001525; C5_MeTfrase.
 IPR022702; Cytosine_MeTrfase1_RFD.
 IPR010506; DMAP1-bd.
 IPR017198; DNA_C5-MeTrfase_1_euk.
 IPR002857; Znf_CXXC. 
Pfam
 PF01426; BAH
 PF06464; DMAP_binding
 PF00145; DNA_methylase
 PF12047; DNMT1-RFD
 PF02008; zf-CXXC 
SMART
 SM00439; BAH 
PROSITE
 PS51038; BAH
 PS00094; C5_MTASE_1
 PS00095; C5_MTASE_2
 PS51058; ZF_CXXC 
PRINTS
 PR00105; C5METTRFRASE.