UniProt Accession

 KAT7_MOUSE; Q5SVQ0; Q5SVQ1; Q5SVQ2; Q5SVQ3; Q5SVQ7; Q6PGC6; Q80Y65 

Genbank Protein ID

 AL627222; AL627222; AL627222; AL627222; AL627222; AL627222; BC057102; BC048904 

Genbank Nucleotide ID

 CAI24800.1; CAI24801.1; CAI24802.1; CAI24803.1; CAI24804.1; CAI24805.1; AAH57102.1; AAH48904.1 

Protein Name

 Histone acetyltransferase KAT7 

Protein Synonyms/Alias

 Histone acetyltransferase binding to ORC1; Lysine acetyltransferase 7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; MYST-2 

Gene Name

 Kat7 

Gene Synonyms/Alias

 Hbo1; Myst2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
157	SHDESIAKDMSLKDS	acetylation	[1]
201	SLGHLTGKHERHFSI	acetylation	[1, 2]
223	NLSADECKVRAQSRD	acetylation	[1]
279	KRNSGLSKEQKEKYM	acetylation	[2, 3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription (By similarity). 

Sequence Annotation

 ZN_FING 368 390 C2HC-type.
 REGION 484 490 Acetyl-CoA binding (By similarity).
 ACT_SITE 434 434 By similarity.
 ACT_SITE 476 476 Nucleophile (By similarity).
 BINDING 479 479 Acetyl-CoA (By similarity).
 BINDING 514 514 Acetyl-CoA (By similarity).
 MOD_RES 52 52 Phosphoserine (By similarity).
 MOD_RES 59 59 Phosphoserine; by PLK1 (By similarity).
 MOD_RES 87 87 Phosphothreonine; by CDK1 (By
 MOD_RES 90 90 Phosphothreonine; by CDK1 (By
 MOD_RES 104 104 Phosphoserine (By similarity).
 MOD_RES 126 126 Phosphoserine (By similarity).
 MOD_RES 164 164 Phosphoserine (By similarity).
 MOD_RES 166 166 Phosphoserine (By similarity).
 MOD_RES 201 201 N6-acetyllysine (By similarity).
 MOD_RES 434 434 N6-acetyllysine; by autocatalysis (By
 MOD_RES 508 508 Phosphoserine (By similarity).  

Keyword

 Acetylation; Acyltransferase; Alternative splicing; Chromatin regulator; Complete proteome; DNA replication; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Transferase; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 613 AA 

Protein Sequence

Gene Ontology

 GO:0000123; C:histone acetyltransferase complex; ISS:UniProtKB.
 GO:0004402; F:histone acetyltransferase activity; IEA:EC.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006260; P:DNA replication; ISS:UniProtKB.
 GO:0043966; P:histone H3 acetylation; ISS:UniProtKB.
 GO:0043983; P:histone H4-K12 acetylation; ISS:UniProtKB.
 GO:0043981; P:histone H4-K5 acetylation; ISS:UniProtKB.
 GO:0043982; P:histone H4-K8 acetylation; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR016181; Acyl_CoA_acyltransferase.
 IPR002717; MOZ_SAS.
 IPR015880; Znf_C2H2-like.
 IPR002515; Znf_C2HC. 

Pfam

 PF01853; MOZ_SAS
 PF01530; zf-C2HC 

SMART

 SM00355; ZnF_C2H2 

PROSITE

  

PRINTS