CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015130
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger MIZ domain-containing protein 1 
Protein Synonyms/Alias
 PIAS-like protein Zimp10; Retinoic acid-induced protein 17 
Gene Name
 Zmiz1 
Gene Synonyms/Alias
 Rai17; Zimp10 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
703SVLQGLLKKRLLPAEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (By similarity). 
Sequence Annotation
 ZN_FING 734 811 SP-RING-type.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1072 AA 
Protein Sequence
MNSMDRHIQQ TNDRLQCIKQ HLQNPANFHN AATELLDWCG DPRAFQRPFE QSLMGCLTVV 60
SRVAAQQGFD LDLGYRLLAV CAANRDKFTP KSAALLSSWC EELGRLLLLR HQKSRQNDPP 120
GKLPMQPPLS SMSSMKPTLS HSDGSFPYDS VPWQQNTNQP PGSLSVVTTV WGVTNTSQSQ 180
VLGNPMANAN NPMNPGGNPM ASGMSTSNPG INSPQFAGQQ QQFSTKAGPA QPYIQPNMYG 240
RPGYPGSGGF GASYPGGPSA PAGMGIPPHT RPPADFTQPA AAAAAAAVAA AAATATATAT 300
ATVAALQETQ NKDINQYGPV CSSFQMGPTQ AYNSQFMNQP GPRGPASMGG SLNPAGMAAG 360
MTPSGMSGPP MGMNQPRPPG ISPFGTHGQR MPQQTYPGPR PQSLPIQSIK RPYPGEPNYG 420
NQQYGPNSQF PTQPGQYPTP NPPRPLTSPN YPGQRMPSQP STGQYPPPTV NMGQYYKPEQ 480
FNGQNNTFSS GSSYSSYSQG SVNRPPRPVP VANYPHSPVP GNPTPPMTPG SSIPPYLSPS 540
QDVKPPFPPD IKPNMSALPP PPANHNDELR LTFPVRDGVV LEPFRLEHNL AVSNHVFHLR 600
PTVHQTLMWR SDLELQFKCY HHEDRQMNTN WPASVQVSVN ATPLTIERGD NKTSHKPLHL 660
KHVCQPGRNT IQITVTACCC SHLFVLQLVH RPSVRSVLQG LLKKRLLPAE HCITKIKRNF 720
SSVAASSGNT TLNGEDGVEQ TAIKVSLKCP ITFRRIQLPA RGHDCKHVQC FDLESYLQLN 780
CERGTWRCPV CNKTALLEGL EVDQYMWGIL NAIQHSEFEE VTIDPTCSWR PVPIKSDLHI 840
KDDPDGIPSK RFKTMSPSQM IMPNVMEMIA ALGPGPSPYP LPPPPGGTSS NDYSSQGNNY 900
QGHGNFDFPH GNPGGTSMND FMHGPPQLSH PPDMPNNMAA LEKPLSHPMQ ETMPHAGSSD 960
QPHPSIQQGL HVPHPSSQAG PPLHHSGAPP PSQPPRQPPQ AAPGNHPHSD LTFNPSSALE 1020
GQAGAQGASD MPEPSLDLLP ELTNPDELLS YLDPPDLPSN SNDDLLSLFE NN 1072 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0048844; P:artery morphogenesis; IMP:MGI.
 GO:0007569; P:cell aging; IDA:MGI.
 GO:0048589; P:developmental growth; IMP:MGI.
 GO:0003007; P:heart morphogenesis; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0048146; P:positive regulation of fibroblast proliferation; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0001570; P:vasculogenesis; IMP:MGI.
 GO:0007296; P:vitellogenesis; IMP:MGI. 
Interpro
 IPR004181; Znf_MIZ.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF02891; zf-MIZ 
SMART
  
PROSITE
 PS51044; ZF_SP_RING 
PRINTS