UniProt Accession

 CDC26_RAT; Q6YDN7 

Genbank Protein ID

 AY156922; BC086343 

Genbank Nucleotide ID

 AAO18338.1; AAH86343.1 

Protein Name

 Anaphase-promoting complex subunit CDC26 

Protein Synonyms/Alias

 Cell division cycle protein 26 homolog; Protein BWK-2 

Gene Name

 Cdc26 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
68	INDRIGYKPQLKTNN	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity). 

Sequence Annotation

 MOD_RES 42 42 Phosphoserine (By similarity).  

Keyword

 Cell cycle; Cell division; Coiled coil; Complete proteome; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 85 AA 

Protein Sequence

Gene Ontology

 GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
 GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.
 GO:0030071; P:regulation of mitotic metaphase/anaphase transition; IEA:InterPro. 

Interpro

 IPR018860; APC_suCDC26. 

Pfam

 PF10471; APC_CDC26 

SMART

  

PROSITE

  

PRINTS