UniProt Accession

 BECN1_MOUSE; O88597; Q99J03 

Genbank Protein ID

 AF077302; AK032176; AK050329; AK083800; AL590969; BC005770 

Genbank Nucleotide ID

 AAC68654.2; BAC27745.1; BAC34192.1; BAC39021.1; CAM19559.1; AAH05770.1 

Protein Name

 Beclin-1 

Protein Synonyms/Alias

 Coiled-coil myosin-like BCL2-interacting protein 

Gene Name

 Becn1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
428	EQWTKALKFMLTNLK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. 

Sequence Annotation

 MOTIF 106 125 BH3 (By similarity).
 MOD_RES 117 117 Phosphothreonine; by DAPK1 (By  

Keyword

 3D-structure; Antiviral defense; Autophagy; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Golgi apparatus; Membrane; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 448 AA 

Protein Sequence

Gene Ontology

 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:MGI.
 GO:0005856; C:cytoskeleton; ISS:MGI.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; ISS:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0043234; C:protein complex; IDA:MGI.
 GO:0005802; C:trans-Golgi network; IDA:MGI.
 GO:0000045; P:autophagic vacuole assembly; IEA:Compara.
 GO:0006914; P:autophagy; IDA:MGI.
 GO:0050435; P:beta-amyloid metabolic process; IMP:MGI.
 GO:0071275; P:cellular response to aluminum ion; IEA:Compara.
 GO:0000910; P:cytokinesis; ISS:UniProtKB.
 GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
 GO:0007040; P:lysosome organization; IMP:MGI.
 GO:0060548; P:negative regulation of cell death; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IDA:MGI.
 GO:0048666; P:neuron development; IMP:MGI.
 GO:0016239; P:positive regulation of macroautophagy; IGI:MGI.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0051707; P:response to other organism; IDA:MGI.
 GO:0033197; P:response to vitamin E; IEA:Compara. 

Interpro

 IPR007243; Beclin_fam. 

Pfam

 PF04111; APG6 

SMART

  

PROSITE

  

PRINTS