UniProt Accession

 E9PUX4_MOUSE; E9PUX4 

Genbank Protein ID

 AC124399 

Genbank Nucleotide ID

  

Protein Name

 60S ribosomal protein L6 

Protein Synonyms/Alias

  

Gene Name

 Gm5428 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
95	EKKKKKEKVLATVTK	ubiquitination	[1]
102	KVLATVTKTVGGDKN	acetylation	[2, 3]
102	KVLATVTKTVGGDKN	succinylation	[3]
102	KVLATVTKTVGGDKN	ubiquitination	[1]
139	KLLSHGKKPFSQHVR	acetylation	[3]
139	KLLSHGKKPFSQHVR	succinylation	[3]
200	PLRRTHQKFVIATST	acetylation	[2]
208	FVIATSTKVDISDVK	ubiquitination	[1]
215	KVDISDVKIPKHLTD	acetylation	[3, 4]
215	KVDISDVKIPKHLTD	succinylation	[3]
215	KVDISDVKIPKHLTD	ubiquitination	[1]
218	ISDVKIPKHLTDAYF	acetylation	[2]
218	ISDVKIPKHLTDAYF	ubiquitination	[1]
226	HLTDAYFKKKQLRKP	acetylation	[2]
226	HLTDAYFKKKQLRKP	ubiquitination	[1]
245	GEIFDTEKEKYEITE	acetylation	[4]
245	GEIFDTEKEKYEITE	ubiquitination	[1]
247	IFDTEKEKYEITEQR	acetylation	[2, 3]
259	EQRKADQKAVDLQIL	acetylation	[4]
259	EQRKADQKAVDLQIL	ubiquitination	[1]
268	VDLQILPKIKAVPQL	acetylation	[3]
268	VDLQILPKIKAVPQL	succinylation	[3]
270	LQILPKIKAVPQLQG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome; Ribonucleoprotein; Ribosomal protein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 296 AA 

Protein Sequence

Gene Ontology

 GO:0005840; C:ribosome; IEA:UniProtKB-KW.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0006412; P:translation; IEA:InterPro. 

Interpro

 IPR014722; Rib_L2_dom2.
 IPR005568; Ribosomal_L6_N.
 IPR000915; Ribosomal_L6E. 

Pfam

 PF01159; Ribosomal_L6e
 PF03868; Ribosomal_L6e_N 

SMART

  

PROSITE

 PS01170; RIBOSOMAL_L6E 

PRINTS