CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032238
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Pre-mRNA-processing-splicing factor 8 
Protein Synonyms/Alias
  
Gene Name
 Prpf8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
43KWQQLQAKRYAEKRKubiquitination[1]
163QPLRDSRKYVNGSTYubiquitination[1]
212LKAFFTSKALNMAIPubiquitination[1]
223MAIPGGPKFEPLVRDubiquitination[1]
311ISHRHSVKSQEPLPDubiquitination[1]
373ALDIPLVKNWYREHCubiquitination[1]
397VSYQKLLKYYVLNALacetylation[2]
554IRMCKDLKHLIYYRFacetylation[2]
647DMMPEGIKQNKARTIubiquitination[1]
691ILRYVKAKADWWTNTubiquitination[1]
965NNVVINYKDMNHTNSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1044 AA 
Protein Sequence
MAGVFPYRGP GNPVPGPLAP LPDYMSEEKL QEKARKWQQL QAKRYAEKRK FGFVDAQKED 60
MPPEHVRKII RDHGDMTNRK FRHDKRVYLG SMWIMMRREK RDRRHFKRMR FPPFDDEEPP 120
LDYADNILDV EPLEAIQLEL DPEEDAPVLD WFYDHQPLRD SRKYVNGSTY QRWQFTLPMM 180
STLYRLANQL LTDLVDDNYF YLFDLKAFFT SKALNMAIPG GPKFEPLVRD INLQDEDWNE 240
FNDINKIIIR QPIRTEYKIA FPYLYNNLPH HVHLTWYHTP NVVFIKTEDP DLPAFYFDPL 300
INPISHRHSV KSQEPLPDDD EEFELPEFVE PFLKDTPLYT DNTANGIALL WAPRPFNLRS 360
GRTRRALDIP LVKNWYREHC PAGQPVKVRV SYQKLLKYYV LNALKHRPPK AQKKRYLFRS 420
FKATKFFQST KLDWVEVGLQ VCRQGYNMLN LLIHRKNLNY LHLDYNFNLK PVKTLTTKER 480
KKSRFGNAFH LCREVLRLTK LVVDSHVQYR LGNVDAFQLA DGLQYIFAHV GQLTGMYRYK 540
YKLMRQIRMC KDLKHLIYYR FNTGPVGKGP GCGFWAAGWR VWLFFMRGIT PLLERWLGNL 600
LARQFEGRHS KGVAKTVTKQ RVESHFDLEL RAAVMHDILD MMPEGIKQNK ARTILQHLSE 660
AWRCWKANIP WKVPGLPTPI ENMILRYVKA KADWWTNTAH YNRERIRRGA TVDKTVCKKN 720
LGRLTRLYLK AEQERQHNYL KDGPYITAEE AVAVYTTTVH WLESRRFSPI PFPPLSYKHD 780
TKLLILALER LKEAYSVKSR LNQSQREELG LIEQAYDNPH EALSRIKRHL LTQRAFKEVG 840
IEFMDLYSHL VPVYDVEPLE KITDAYLDQY LWYEADKRRL FPPWIKPADT EPPPLLVYKW 900
CQGINNLQDV WETSEGECNV MLESRFEKMY EKIDLTLLNR LLRLIVDHNI ADYMTAKNNV 960
VINYKDMNHT NSYGIIRGLQ FASFIVQYYG LVMDLLVLGL HRASEMAGPP QMPNDFLSFQ 1020
DIATEAAHPI RLFCRYIDRI HIFF 1044 
Gene Ontology
 GO:0005681; C:spliceosomal complex; IEA:InterPro.
 GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro. 
Interpro
 IPR012591; Pre-mRNA-splicing_factor-8.
 IPR012592; PROCN.
 IPR019582; RRM_spliceosomal_PrP8. 
Pfam
 PF08082; PRO8NT
 PF08083; PROCN
 PF10598; RRM_4 
SMART
  
PROSITE
  
PRINTS