| Tag | Content |
|---|
| CPLM ID | CPLM-024190 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Poly [ADP-ribose] polymerase 1 |
Protein Synonyms/Alias | PARP-1; NAD(+) ADP-ribosyltransferase 1; ADPRT-1; Poly[ADP-ribose] synthase 1 |
Gene Name | PARP1 |
Gene Synonyms/Alias | At2g31320; F16D14.16 |
Created Date | July 27, 2013 |
Organism | Arabidopsis thaliana (Mouse-ear cress) |
NCBI Taxa ID | 3702 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 565 | WGRVGNEKIGGNKVE | acetylation | [1] | | 570 | NEKIGGNKVEEMSKS | acetylation | [1] |
|
Reference | [1] Proteins of diverse function and subcellular location are lysine acetylated in Arabidopsis. Finkemeier I, Laxa M, Miguet L, Howden AJ, Sweetlove LJ. Plant Physiol. 2011 Apr;155(4):1779-90. [ PMID: 21311031] |
Functional Description | Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity). |
Sequence Annotation | DOMAIN 394 484 BRCT.
DOMAIN 633 751 PARP alpha-helical.
DOMAIN 758 983 PARP catalytic.
ZN_FING 8 91 PARP-type 1.
ZN_FING 114 194 PARP-type 2. |
Keyword | 3D-structure; ADP-ribosylation; Complete proteome; DNA-binding; Glycosyltransferase; Metal-binding; NAD; Nucleus; Reference proteome; Repeat; Transferase; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 983 AA |
Protein Sequence | MASPHKPWRA EYAKSSRSSC KTCKSVINKE NFRLGKLVQS THFDGIMPMW NHASCILKKT 60
KQIKSVDDVE GIESLRWEDQ QKIRKYVESG AGSNTSTSTG TSTSSTANNA KLEYGIEVSQ 120
TSRAGCRKCS EKILKGEVRI FSKPEGPGNK GLMWHHAKCF LEMSSSTELE SLSGWRSIPD 180
SDQEALLPLV KKALPAAKTE TAEARQTNSR AGTKRKNDSV DNEKSKLAKS SFDMSTSGAL 240
QPCSKEKEME AQTKELWDLK DDLKKYVTSA ELREMLEVNE QSTRGSELDL RDKCADGMMF 300
GPLALCPMCS GHLSFSGGLY RCHGYISEWS KCSHSTLDPD RIKGKWKIPD ETENQFLLKW 360
NKSQKSVKPK RILRPVLSGE TSQGQGSKDA TDSSRSERLA DLKVSIAGNT KERQPWKKRI 420
EEAGAEFHAN VKKGTSCLVV CGLTDIRDAE MRKARRMKVA IVREDYLVDC FKKQRKLPFD 480
KYKIEDTSES LVTVKVKGRS AVHEASGLQE HCHILEDGNS IYNTTLSMSD LSTGINSYYI 540
LQIIQEDKGS DCYVFRKWGR VGNEKIGGNK VEEMSKSDAV HEFKRLFLEK TGNTWESWEQ 600
KTNFQKQPGK FLPLDIDYGV NKQVAKKEPF QTSSNLAPSL IELMKMLFDV ETYRSAMMEF 660
EINMSEMPLG KLSKHNIQKG FEALTEIQRL LTESDPQPTM KESLLVDASN RFFTMIPSIH 720
PHIIRDEDDF KSKVKMLEAL QDIEIASRIV GFDVDSTESL DDKYKKLHCD ISPLPHDSED 780
YRLIEKYLNT THAPTHTEWS LELEEVFALE REGEFDKYAP HREKLGNKML LWHGSRLTNF 840
VGILNQGLRI APPEAPATGY MFGKGIYFAD LVSKSAQYCY TCKKNPVGLM LLSEVALGEI 900
HELTKAKYMD KPPRGKHSTK GLGKKVPQDS EFAKWRGDVT VPCGKPVSSK VKASELMYNE 960
YIVYDTAQVK LQFLLKVRFK HKR 983 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |