CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022429
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Constitutive coactivator of PPAR-gamma-like protein 1 
Protein Synonyms/Alias
 Oxidative stress-associated Src activator; Protein FAM120A 
Gene Name
 FAM120A 
Gene Synonyms/Alias
 C9orf10; KIAA0183; OSSA 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
12GFQDYIEKHCPSAVVubiquitination[1]
25VVPVELQKLARGSLVubiquitination[1]
110ARLHEWVKRQGNERQubiquitination[1]
210LKLSRNGKSLTTSQYubiquitination[1]
304SDLDAIAKDVFQHSQubiquitination[1, 2]
701EWTCPNLKRLWLGKAubiquitination[1]
838DGKLFQSKLLKASREubiquitination[1]
846LLKASREKTPLIDLCubiquitination[1]
960SDSSRTSKSQGGVQPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May participate in mRNA transport in the cytoplasm (By similarity). Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous- type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses. 
Sequence Annotation
 REGION 339 405 Interaction with YES1, SRC and FYN.
 REGION 829 1118 RNA binding.
 MOD_RES 1023 1023 Phosphoserine.
 MOD_RES 1044 1044 Phosphoserine.
 MOD_RES 1045 1045 Phosphoserine.
 MOD_RES 1048 1048 Phosphoserine.  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding; Tumor suppressor. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1118 AA 
Protein Sequence
MGVQGFQDYI EKHCPSAVVP VELQKLARGS LVGGGRQRPP QTPLRLLVDA DNCLHRLYGG 60
FYTDWVSGGQ WNHMLGYLAA LAKACFGGNI ELFVFFNGAL EKARLHEWVK RQGNERQTAQ 120
QIVSHVQNKG TPPPKVWFLP PVCMAHCIRL ALIRFHVKVA QSIEDHHQEV IGFCRENGFH 180
GLVAYDSDYA LCNIPYYFSA HALKLSRNGK SLTTSQYLMH EVAKQLDLNP NRFPIFAALL 240
GNHILPDEDL ASFHWSLLGP EHPLASLKVR AHQLVLPPCD VVIKAVADYV RNIQDTSDLD 300
AIAKDVFQHS QSRTDDKVIR FKRAIGYYSA TSKPMSFHPP HYLAARPGPF GMPGMVPPHV 360
PPQMLNIPQT SLQAKPVAPQ VPSPGGAPGQ GPYPYSLSEP APLTLDTSGK NLTEQNSYSN 420
IPHEGKHTPL YERSSPINPA QSGSPNHVDS AYFPGSSTSS SSDNDEGSGG ATKPFQLYLQ 480
KNFVFHKENS IVLCSRILRH GHISGNKIGW EKTGSHSEPQ ARGDPGDQTK AEGSSTASSG 540
SQLAEGKGSQ MGTVQPIPCL LSMPTRNHMD ITTPPLPPVA PEVLRVAEHR HKKGLMYPYI 600
FHVLTKGEIK IAVSIEDEAN KDLPPAALLY RPVRQYVYGV LFSLAESRKK TERLAFRKNR 660
LPPEFSPVII KEWAAYKGKS PQTPELVEAL AFREWTCPNL KRLWLGKAVE DKNRRMRAFL 720
ACMRSDTPAM LNPANVPTHL MVLCCVLRYM VQWPGARILR RQELDAFLAQ ALSPKLYEPD 780
QLQELKIENL DPRGIQLSAL FMSGVDMALF ANDACGQPIP WEHCCPWMYF DGKLFQSKLL 840
KASREKTPLI DLCDGQADQA AKVEKMRQSV LEGLSFSRQS HTLPFPPPPA LPFYPASAYP 900
RHFGPVPPSQ GRGRGFAGVC GFGGPYGETV ATGPYRAFRV AAASGHCGAF SGSDSSRTSK 960
SQGGVQPIPS QGGKLEIAGT VVGHWAGSRR GRGGRGPFPL QVVSVGGPAR GRPRGVISTP 1020
VIRTFGRGGR YYGRGYKNQA AIQGRPPYAA SAEEVAKELK SKSGESKSSA MSSDGSLAEN 1080
GVMAEEKPAP QMNGSTGDAR APSHSESALN NDSKTCNTNP HLNALSTDSA CRREAALEAA 1140
VLNKEE 1146 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW. 
Interpro
 IPR026783; Coact_PPARg-like_1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS