CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040045
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 
Protein Synonyms/Alias
  
Gene Name
 PIK3CD 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
39VCSEPVWKQRLEFDIubiquitination[1]
116WPSVPDEKGELLNPTubiquitination[1]
195GELYEHEKDLVWKLRubiquitination[1]
200HEKDLVWKLRHEVQEubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 319 AA 
Protein Sequence
MIPESSELVV QAGLFHGNEM LCKTVSSSEV SVCSEPVWKQ RLEFDINICD LPRMARLCFA 60
LYAVIEKAKK ARSTKKKSKK ADCPIAWANL MLFDYKDQLK TGERCLYMWP SVPDEKGELL 120
NPTGTVRSNP NTDSAAALLI CLPEVAPHPV YYPALEKILE LGRHSECVHV TEEEQLQLRE 180
ILERRGSGEL YEHEKDLVWK LRHEVQEHFP EALARLLLVT KWNKHEDVAQ MLYLLCSWPE 240
LPVLSALELL DFSFPDCHVG SFAIKSLRKL TDDELFQYLL QLVQVLKYES YLDCELTKFL 300
LDRALANRKI GHFLFWHLR 319 
Gene Ontology
 GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
 GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR002420; PI3K_C2_dom.
 IPR015433; PI_Kinase.
 IPR001263; PInositide-3_kin_accessory_dom. 
Pfam
 PF00792; PI3K_C2
 PF00613; PI3Ka 
SMART
 SM00142; PI3K_C2
 SM00145; PI3Ka 
PROSITE
 PS51547; PI3K_C2
 PS51545; PIK_HELICAL 
PRINTS