UniProt Accession

 AT1B1_RAT; P07340; Q63062 

Genbank Protein ID

 M14137; J02701; BC078902; X63375 

Genbank Nucleotide ID

 AAA40781.1; AAA40780.1; AAH78902.1 

Protein Name

 Sodium/potassium-transporting ATPase subunit beta-1 

Protein Synonyms/Alias

 Sodium/potassium-dependent ATPase subunit beta-1 

Gene Name

 Atp1b1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
7	*MARGKAKEEGSWKK	acetylation	[1]
7	*MARGKAKEEGSWKK	ubiquitination	[2]
14	KEEGSWKKFIWNSEK	acetylation	[1]
14	KEEGSWKKFIWNSEK	ubiquitination	[2]
21	KFIWNSEKKEFLGRT	acetylation	[1]
22	FIWNSEKKEFLGRTG	acetylation	[1]
85	TQIPQIQKTEISFRP	acetylation	[1]
111	NIIRFLEKYKDSAQK	acetylation	[1]
179	GKPCIIIKLNRVLGF	acetylation	[1]
289	ENIGYSEKDRFQGRF	acetylation	[1]
299	FQGRFDVKIEVKS**	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. 

Sequence Annotation

 REGION 191 304 immunoglobulin-like (By similarity).
 MOD_RES 101 101 Phosphotyrosine (By similarity).
 CARBOHYD 158 158 N-linked (GlcNAc...) (By similarity).
 CARBOHYD 193 193 N-linked (GlcNAc...) (By similarity).
 CARBOHYD 266 266 N-linked (GlcNAc...) (By similarity).
 DISULFID 126 149 By similarity.
 DISULFID 159 175 By similarity.
 DISULFID 214 277 By similarity.  

Keyword

 Cell adhesion; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Potassium; Potassium transport; Reference proteome; Signal-anchor; Sodium; Sodium transport; Sodium/potassium transport; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 304 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IDA:RGD.
 GO:0016323; C:basolateral plasma membrane; IDA:RGD.
 GO:0005901; C:caveola; IDA:RGD.
 GO:0005890; C:sodium:potassium-exchanging ATPase complex; IDA:RGD.
 GO:0005391; F:sodium:potassium-exchanging ATPase activity; IDA:RGD.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0001666; P:response to hypoxia; IDA:RGD. 

Interpro

 IPR000402; Na/K_ATPase_sub_beta.
 IPR015565; Na/K_ATPase_sub_beta_chordates. 

Pfam

 PF00287; Na_K-ATPase 

SMART

  

PROSITE

 PS00390; ATPASE_NA_K_BETA_1
 PS00391; ATPASE_NA_K_BETA_2 

PRINTS