UniProt Accession

 ARL4C_HUMAN; P56559; Q53R10; Q9BVN1; Q9UQ34 

Genbank Protein ID

 Y17804; AJ579851; AF493892; BT019378; BT019379; AK314119; AC097713; CH471063; BC001051; BC089043; AB016811 

Genbank Nucleotide ID

 CAB44355.1; CAE30323.1; AAM12606.1; AAV38185.1; AAV38186.1; BAG36810.1; AAX93114.1; EAW71073.1; AAH89043.1; BAA75473.1 

Protein Name

 ADP-ribosylation factor-like protein 4C 

Protein Synonyms/Alias

 ADP-ribosylation factor-like protein 7; ADP-ribosylation factor-like protein LAK 

Gene Name

 ARL4C 

Gene Synonyms/Alias

 ARL7 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
113	TELHKVTKFAENQGT	ubiquitination	[1, 2, 3]
128	PLLVIANKQDLPKSL	ubiquitination	[2]
133	ANKQDLPKSLPVAEI	ubiquitination	[2, 3]
181	KLYEMILKRRKSLKQ	ubiquitination	[4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP- bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process. 

Sequence Annotation

 NP_BIND 20 27 GTP (By similarity).
 NP_BIND 68 72 GTP (By similarity).
 NP_BIND 127 130 GTP (By similarity).
 LIPID 2 2 N-myristoyl glycine (Potential).  

Keyword

 Cell membrane; Cell projection; Complete proteome; Cytoplasm; GTP-binding; Lipoprotein; Membrane; Myristate; Nucleotide-binding; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 192 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0043014; F:alpha-tubulin binding; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; TAS:ProtInc.
 GO:0032456; P:endocytic recycling; IDA:UniProtKB.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR024156; Small_GTPase_ARF.
 IPR006689; Small_GTPase_ARF/SAR. 

Pfam

 PF00025; Arf 

SMART

 SM00177; ARF 

PROSITE

 PS51417; ARF 

PRINTS

 PR00328; SAR1GTPBP.