UniProt Accession

 RBBP9_HUMAN; O75884; D3DW31; Q5JPH9; Q9H1D8 

Genbank Protein ID

 AF039564; AF237576; AL832411; AL121893; CH471133; CH471133; CH471133; BC015938 

Genbank Nucleotide ID

 AAC63498.1; AAL83721.1; CAI46193.1; CAC11112.1; EAX10236.1; EAX10237.1; EAX10238.1; AAH15938.1 

Protein Name

 Putative hydrolase RBBP9 

Protein Synonyms/Alias

 B5T-overexpressed gene protein; Protein BOG; Retinoblastoma-binding protein 10; RBBP-10; Retinoblastoma-binding protein 9; RBBP-9 

Gene Name

 RBBP9 

Gene Synonyms/Alias

 BOG; RBBP10 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
156	VADRLETKLHKFTDC	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1. 

Sequence Annotation

 REGION 56 70 Retinoblastoma protein binding
 ACT_SITE 75 75 Charge relay system (Potential).
 ACT_SITE 138 138 Charge relay system (Potential).
 ACT_SITE 165 165 Charge relay system (Potential).
 MOD_RES 49 49 Phosphothreonine; by CK2 (Potential).
 MOD_RES 135 135 Phosphoserine; by CK2 (Potential).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 186 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara. 

Interpro

 IPR010662; DUF1234_Hydrolase. 

Pfam

 PF06821; Ser_hydrolase 

SMART

  

PROSITE

  

PRINTS