UniProt Accession

 NPTN_RAT; P97546; P97547; Q6IRE8 

Genbank Protein ID

 X99337; X99338; BC070947 

Genbank Nucleotide ID

 CAA67711.1; CAA67712.1; AAH70947.1 

Protein Name

 Neuroplastin 

Protein Synonyms/Alias

 Glycoprotein 55/65; gp55/65; Stromal cell-derived receptor 1; SDR-1 

Gene Name

 Nptn 

Gene Synonyms/Alias

 Sdfr1; Sdr1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
147	ATISVLQKPRIVTSE	methylation	[1]

Reference

 [1] A method for the comprehensive proteomic analysis of membrane proteins.
 Wu CC, MacCoss MJ, Howell KE, Yates JR 3rd.
 Nat Biotechnol. 2003 May;21(5):532-8. [PMID: 12692561] 

Functional Description

 Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity. 

Sequence Annotation

 DOMAIN 29 134 Ig-like 1.
 DOMAIN 148 234 Ig-like 2.
 DOMAIN 237 327 Ig-like 3.
 REGION 149 161 Narpin; mediates binding with FGFR1 and
 CARBOHYD 170 170 N-linked (GlcNAc...).
 CARBOHYD 196 196 N-linked (GlcNAc...) (Potential).
 CARBOHYD 228 228 N-linked (GlcNAc...).
 CARBOHYD 283 283 N-linked (GlcNAc...).
 CARBOHYD 295 295 N-linked (GlcNAc...).
 CARBOHYD 316 316 N-linked (GlcNAc...) (Potential).
 DISULFID 52 116 By similarity.
 DISULFID 169 217
 DISULFID 258 315  

Keyword

 3D-structure; Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Neurogenesis; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 393 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; TAS:BHF-UCL.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; TAS:HGNC.
 GO:0042734; C:presynaptic membrane; IDA:HGNC.
 GO:0050839; F:cell adhesion molecule binding; IDA:HGNC.
 GO:0005105; F:type 1 fibroblast growth factor receptor binding; IDA:UniProtKB.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IDA:UniProtKB.
 GO:0007156; P:homophilic cell adhesion; IDA:HGNC.
 GO:0060291; P:long-term synaptic potentiation; IDA:UniProtKB.
 GO:0045743; P:positive regulation of fibroblast growth factor receptor signaling pathway; IDA:UniProtKB.
 GO:0048170; P:positive regulation of long-term neuronal synaptic plasticity; IMP:HGNC.
 GO:0010976; P:positive regulation of neuron projection development; IDA:UniProtKB.
 GO:0001934; P:positive regulation of protein phosphorylation; IDA:UniProtKB.
 GO:0030155; P:regulation of cell adhesion; TAS:HGNC. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR027112; Neuroplastin. 

Pfam

 PF07679; I-set 

SMART

 SM00409; IG
 SM00408; IGc2 

PROSITE

 PS50835; IG_LIKE 

PRINTS