UniProt Accession

 KAP3_MOUSE; P31324; B1B199; Q3UTZ1; Q80ZM4; Q8BRZ7 

Genbank Protein ID

 AK041013; AK138963; CT010463; BC048710; M68861 

Genbank Nucleotide ID

 BAC30779.1; BAE23838.1; CAM17140.1; AAH48710.1; AAA40057.1 

Protein Name

 cAMP-dependent protein kinase type II-beta regulatory subunit 

Protein Synonyms/Alias

  

Gene Name

 Prkar2b 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
174	AMFEKLVKEGEHVID	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. 

Sequence Annotation

 NP_BIND 152 273 cAMP 1.
 NP_BIND 274 416 cAMP 2.
 REGION 1 151 Dimerization and phosphorylation.
 BINDING 221 221 cAMP 1 (By similarity).
 BINDING 230 230 cAMP 1 (By similarity).
 BINDING 350 350 cAMP 2 (By similarity).
 BINDING 359 359 cAMP 2 (By similarity).
 MOD_RES 83 83 Phosphoserine (By similarity).
 MOD_RES 85 85 Phosphoserine (By similarity).
 MOD_RES 112 112 Phosphoserine.  

Keyword

 3D-structure; cAMP; cAMP-binding; Cell membrane; Complete proteome; Cytoplasm; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 416 AA 

Protein Sequence

Gene Ontology

 GO:0005952; C:cAMP-dependent protein kinase complex; IEA:Compara.
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
 GO:0008603; F:cAMP-dependent protein kinase regulator activity; IDA:MGI.
 GO:0008283; P:cell proliferation; TAS:MGI.
 GO:0006631; P:fatty acid metabolic process; IMP:MGI.
 GO:0007612; P:learning; IMP:MGI.
 GO:0009887; P:organ morphogenesis; TAS:MGI.
 GO:0006468; P:protein phosphorylation; TAS:MGI.
 GO:0097332; P:response to antipsychotic drug; IEA:Compara.
 GO:0097338; P:response to clozapine; IEA:Compara.
 GO:0007165; P:signal transduction; IEA:InterPro. 

Interpro

 IPR002373; cAMP/cGMP_kin.
 IPR012198; cAMP_dep_PK_reg_su.
 IPR003117; cAMP_dep_PK_reg_su_I/II_a/b.
 IPR018490; cNMP-bd-like.
 IPR018488; cNMP-bd_CS.
 IPR000595; cNMP-bd_dom.
 IPR014710; RmlC-like_jellyroll. 

Pfam

 PF00027; cNMP_binding
 PF02197; RIIa 

SMART

 SM00100; cNMP
 SM00394; RIIa 

PROSITE

 PS00888; CNMP_BINDING_1
 PS00889; CNMP_BINDING_2
 PS50042; CNMP_BINDING_3 

PRINTS

 PR00103; CAMPKINASE.