CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020138
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein canopy homolog 3 
Protein Synonyms/Alias
 CTG repeat protein 4a; Expanded repeat-domain protein CAG/CTG 5; Protein associated with TLR4; Trinucleotide repeat-containing gene 5 protein 
Gene Name
 CNPY3 
Gene Synonyms/Alias
 CTG4A; ERDA5; PRAT4A; TNRC5; HSPC084; UNQ1934/PRO4409 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
48DWVRLPSKCEGTCG*ubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptative immune responses (By similarity). 
Sequence Annotation
 DOMAIN 47 271 Saposin B-type.
 CARBOHYD 153 153 N-linked (GlcNAc...).
 DISULFID 49 206 By similarity.
 DISULFID 52 194 By similarity.
 DISULFID 104 166 By similarity.  
Keyword
 Alternative splicing; Chaperone; Coiled coil; Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Immunity; Innate immunity; Polymorphism; Reference proteome; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 278 AA 
Protein Sequence
MDSMPEPASR CLLLLPLLLL LLLLLPAPEL GPSQAGAEEN DWVRLPSKCE GTCG 54 
Gene Ontology
 GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0002224; P:toll-like receptor signaling pathway; TAS:Reactome. 
Interpro
 IPR021852; DUF3456. 
Pfam
 PF11938; DUF3456 
SMART
  
PROSITE
 PS50015; SAP_B 
PRINTS