| Tag | Content |
|---|
| CPLM ID | CPLM-012434 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Molybdenum cofactor sulfurase |
Protein Synonyms/Alias | MCS; MOS; MoCo sulfurase; Molybdenum cofactor sulfurtransferase |
Gene Name | Mocos |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 287 | HVAPLLRKGYFGGGT | ubiquitination | [1] | | 684 | NVSRWLSKFLGRLCH | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form (By similarity). |
Sequence Annotation | DOMAIN 704 855 MOSC.
ACT_SITE 424 424 By similarity.
MOD_RES 264 264 N6-(pyridoxal phosphate)lysine (By
MOD_RES 517 517 Phosphoserine (By similarity). |
Keyword | Complete proteome; Molybdenum cofactor biosynthesis; Phosphoprotein; Pyridoxal phosphate; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 862 AA |
Protein Sequence | MACGAAERGP EPPAFQRHLE ASTQRLAHGY GLRSMSELRD QEFGRLAGTV YLDHAGATLF 60
PQSQLTNFTK DLMENVYGNP HSQNITSKLT HDTVEQVRYR ILTHFHTTPE DYIVIFTAGS 120
TAALRLVAEA FPWVSRSPEN SGSHFCYLTD NHTSVVGMRK VAAAMSVTSI PVKPEDMWSA 180
EGKDAGACDP DCQLPHLFCY PAQSNFSGTR YPLSWVEEVK SGRRSPVNAP GKWFVLLDAA 240
SYVSTSPLDL SAHQADFIPI SFYKIFGLPT GLGALLVNKH VAPLLRKGYF GGGTAAAYLA 300
GEDFYVPRSS VAERFEDGTI SFLDVIALKH GFDALEHLTG GMVNIQQHTF ALVQYTHSAL 360
SSLRYLNGAP VVRIYSDSEF SSPDVQGPII NFNVLDDGGK IIGYSQVDKM ASLYNIHLRT 420
GCFCNLGACQ RHLGLSDEMV KKHFQAGHVC GDDVDIIDGR PTGSVRISFG YMSTLEDAQA 480
FLRFISTIYL RSPSDQPVPQ ASISDAGALT SKSDCHSPQE GSCTDPSVCN GSYPDTNIMD 540
LHPSLSKASS AQQTPQDKAA GILNGDPGSH IVTNIYLYPI KSCAAFEVTK WPVGSQGLLY 600
DRSWMVVNHN GICMSQKQEP RLCLIQPFID LQQRIMVIKA EGMEPIQVPL EEDGEQTQIC 660
QSRVCADRVN TYDCGENVSR WLSKFLGRLC HLIKQSPHFQ RNARKTPKKG QPPGTTVALS 720
LVNEAQYLLV NTSSILELQR QLNASDEHGK EESFSMKDLI SRFRANIITK GARAFEEEKW 780
DEISIGSLHF QVLGPCHRCQ MICINQQTGQ RNQDVFQTLS ESRGRKVNFG VYLMHSYLDL 840
SSPCFLSVGS EVLPVLKDCG VS 862 |
Gene Ontology | GO:0008265; F:Mo-molybdopterin cofactor sulfurase activity; ISS:UniProtKB. GO:0030151; F:molybdenum ion binding; IEA:InterPro. GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. GO:0016740; F:transferase activity; IEA:UniProtKB-KW. GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-KW. GO:0043545; P:molybdopterin cofactor metabolic process; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |