UniProt Accession

 LPP3_RAT; P97544 

Genbank Protein ID

 Y07783 

Genbank Nucleotide ID

 CAA69106.1 

Protein Name

 Lipid phosphate phosphohydrolase 3 

Protein Synonyms/Alias

 Differentially expressed in rat intestine 42; Dri42; PAP2-beta; Phosphatidate phosphohydrolase type 2b; Phosphatidic acid phosphatase 2b; PAP-2b; PAP2b 

Gene Name

 Ppap2b 

Gene Synonyms/Alias

 Lpp3 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
5	***MQSYKYDKAIVP	ubiquitination	[1]
8	MQSYKYDKAIVPESK	ubiquitination	[1, 2]
15	KAIVPESKNGGSPAL	ubiquitination	[1, 2]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P) (By similarity). Involved in the regulation of epithelial differentiation. 

Sequence Annotation

 MOD_RES 19 19 Phosphoserine (By similarity).
 MOD_RES 298 298 Phosphoserine (By similarity).
 CARBOHYD 171 171 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Endoplasmic reticulum; Glycoprotein; Hydrolase; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 312 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IDA:RGD.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008195; F:phosphatidate phosphatase activity; IEA:EC.
 GO:0008152; P:metabolic process; IEA:GOC. 

Interpro

 IPR016118; P_Acid_Pase/Cl_peroxidase_N.
 IPR000326; P_Acid_Pase_2/haloperoxidase. 

Pfam

 PF01569; PAP2 

SMART

 SM00014; acidPPc 

PROSITE

  

PRINTS